Total lymphoid irradiation: Critical timing and combination with cyclosporin A for immunosuppression in a rat heart allograft model

Rynasiewicz, John J.; Sutherland, David E.R.; Kawahara, Katsuhiko; Najarían, John S.

doi:10.1016/0022-4804(81)90173-6

Cited by 20 publications

(3 citation statements)

References 5 publications

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“…The combination of TLI and low-dose cyclosporine was found to be effective and clinically safe in rats, 216 and TLI with postoperative antithymocyte globulin induced permanent and specific transplantation tolerance toward heart allografts in about 40% of transplanted dogs. 249 These encouraging results led to a similar trial in clinical kidney transplantation (discussed later).…”

Section: Experimental Experiencementioning

confidence: 97%

Other Forms of Immunosuppression

Sprangers¹,

Pirenne²,

Etten³

et al. 2008

Kidney Transplantation

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Section: Experimental Experiencementioning

confidence: 97%

Other Forms of Immunosuppression

Sprangers¹,

Pirenne²,

Etten³

et al. 2008

Kidney Transplantation

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“…The effect of TLI is dose dependent, however, several aspects of how treatment is given seem to 14 be essential (143,144) and have been the subject to some controversary (145). Preoperative timing, the dose given per session and dose rates may be critical for an optimal recipient preconditioning.…”

Section: Total Lymphoid Irradiationmentioning

confidence: 99%

Pathogenesis and mechanisms of graft rejection in concordant xenotransplantation with special reference to hamster‐to‐rat cardiac transplantation

STEINBRÜCHEL

1996

APMIS

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“…Cyclosporin (CyA) has obvious appeal for use after TLI in view of its marrow-sparing properties. Rynasiewicz et al [26] found a marked synergistic effect between 1,000 cGy of TLI and low doses of CyA (1.25 or 2.5 mg/kg per day) in heterotopic heart transplantation in rabbits. On the other hand, the addition of CyA to TLI in heart transplantation in cynomolgus monkeys did not result in a significant increase in graft survival [24].…”

Section: Adjuvant Immunosuppressive Drug Therapymentioning

confidence: 99%

Total lymphoid irradiation in renal transplantation

et al. 1986

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Total lymphoid irradiation (TLI), used in the treatment of some patients with Hodgkin's disease, produces profound immunological changes. In small rodents, mice and rats, a modified version of TLI results in transplantation tolerance for skin and heart allografts. The concept has been expanded to large outbred animals. In baboons transplantation tolerance has been produced for kidney and liver transplantation. The tolerance meets the in vivo and in vitro immunological requirements of durability and specificity. Baboons are currently surviving with normal graft function more than 6 years after kidney transplantation. Kidney‐donor derived skin grafts are accepted permanently, and third‐party skin and kidney grafts are rejected by these tolerant animals. Late chronic rejection occurs in a minority of animals between 6 and 12 months after transplantation. No grafts have been rejected by baboons with normal graft function at 1 year. The most successful protocol in baboons has involved a low cumulative dose (800 cGy), twice a week fractionation regimen of irradiation administered to a wider field than that used in the treatment of Hodgkin's disease. Up to two‐thirds of such animals are rendered tolerant. The role of adjuvant immunosuppressive drug therapy in increasing the tolerant fraction obtained is currently under evaluation. Encouraging results with the use of several methods of TLI in clinical renal transplantation are emerging from 5 centers. The prospect of achieving transplantation tolerance with TLI in the clinical context may be realized with further experience and modification of techniques.

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Total lymphoid irradiation: Critical timing and combination with cyclosporin A for immunosuppression in a rat heart allograft model

Cited by 20 publications

References 5 publications

Other Forms of Immunosuppression

Other Forms of Immunosuppression

Pathogenesis and mechanisms of graft rejection in concordant xenotransplantation with special reference to hamster‐to‐rat cardiac transplantation

Total lymphoid irradiation in renal transplantation

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