Total leukoderma and leukotrichia in a child after hematopoietic SCT: report of a case and review of the literature

Nambudiri, Vinod E.; Tsiaras, William G.; Schmidt, Birgitta; Huang, Jennifer T.

doi:10.1038/bmt.2013.200

Cited by 8 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitiligo and/or alopecia areata are still considered uncommon phenomena in allo-HSCT recipients, although connection of vitiligo and cGVHD has already been established ( 7 , 9 - 16 ). Alajlan et al ( 7 ) described a patient with multiple myeloma in whom generalized vitiligo developed within 3 months after allo-BMT from his HLA-matched sister with vitiligo, and they proposed that adoptive transfer of donor immunity to the recipient may play a role in the development of vitiligo.…”

Section: Discussionmentioning

confidence: 99%

High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease

et al. 2016

View full text Add to dashboard Cite

AimTo determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD).Methods50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria. The presence of vitiligo, alopecia, xerosis, nail changes, and dyspigmentation was also assessed.ResultsOut of 50 cGVHD patients, 28 (56%) had skin involvement, and 27 of them (96%) had hypo and/or hyperpigmentations. 11 patients (39%) had a mild cutaneous NIH cGVHD score, 22% moderate, and 39% severe. 15 (30%) patients had nail changes and 10 (20%) had vitiligo or alopecia areata. Univariate analysis showed that patients with vitiligo/alopecia areata received more lines of prior systemic immunosuppressive therapy (P = 0.043), had lower Karnofsky performance status (P = 0.028), and had a higher B-cell number (P = 0.005), platelet count (P = 0.022), and total protein (P = 0.024). Vitiligo and alopecia areata were associated with higher NIH skin score (P = 0.001), higher intensity of immunosuppressive treatment (P = 0.020), and total body irradiation conditioning (P = 0.040). Multivariate regression model showed that patients with higher NIH skin scoring were 3.67 times more likely to have alopecia and/or vitiligo (odds ratio 3.67; 95% confidence interval 1.26-10.73), controlled for all other factors in the model (age at study entry, number of B-cells, platelet count, and global NIH score).ConclusionThese data indicate that vitiligo and alopecia areata occur more frequently in cGVHD than previously reported.

show abstract

Section: Discussionmentioning

confidence: 99%

High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…45 following GvHD is unknown; however, it is important to counsel patients on sun protection and screening for skin cancer. 39 It is also important to acknowledge that a few, isolated white hairs may also be an incidental finding without any underlying genetic or systemic abnormality.…”

Section: Other Causesmentioning

confidence: 99%

“…He had no family history of vitiligo or disorder of melanin biosynthesis. The exact mechanism of depigmentation following GvHD is unknown; however, it is important to counsel patients on sun protection and screening for skin cancer 39 …”

Section: Localized Poliosismentioning

confidence: 99%

Poliosis, hair pigment dilution, and premature graying of the hair: A diagnostic approach in pediatric patients and review of the literature

Rangu,

Oza

2023

Pediatric Dermatology

View full text Add to dashboard Cite

Poliosis is defined as the absence of melanin in hair, and hair graying typically occurs with hair melanin reduction. Poliosis can occur at any age but presents in childhood in certain genetic and acquired conditions, with many families seeking evaluation from a pediatric dermatologist. Poliosis presents as white hair typically restricted to a certain location of the scalp. Children may also present with a reduction of expected hair pigmentation, referred to as pigment dilution, or the development of hair graying. This review aims to provide a streamlined diagnostic approach for pediatric dermatologists when presented with these hair findings. Poliosis should be recognized as a potential diagnostic feature or initial sign in many syndromes and thus can guide clinicians in diagnosing and managing conditions earlier in a patient's care. Since many of the genetic and acquired conditions that present with poliosis or hair pigment dilution have extracutaneous manifestations, early diagnosis is vital in establishing multidisciplinary care.

show abstract

Risk Factors and Characterization of Vitiligo and Alopecia Areata in Patients With Chronic Graft-vs-Host Disease

et al. 2015

View full text Add to dashboard Cite

show abstract

Total leukoderma and leukotrichia in a child after hematopoietic SCT: report of a case and review of the literature

Cited by 8 publications

References 11 publications

High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease

High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease

Poliosis, hair pigment dilution, and premature graying of the hair: A diagnostic approach in pediatric patients and review of the literature

Risk Factors and Characterization of Vitiligo and Alopecia Areata in Patients With Chronic Graft-vs-Host Disease

Contact Info

Product

Resources

About