Total knee arthroplasty in severe haemophilic patients under continuous infusion of clotting factors

Abstract

Therapeutic study, Level IV.

Common complications after arthroplasty in patients with haemophilia – a Chinese experience

“…The intraarticular haematoma might easily occur after any arthroplasty, especially in TKA. Studies have reported the incidence of postsurgical bleeding to be 3-52% with a higher risk in the first week [4,6,7]. In our group, the rate of intraarticular haematoma was less than what was previously reported.…”

“…In an evaluation of data from all over the world of survival rates in multifoetal reduction, a lower survival rate has been reported in case of higher order multiple pregnancies as compared to lower order pregnancies i.e. up to quadruplets [7].…”

Mid‐term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: A review of consecutive 131 knees between 2006 and 2015 in a single institute

“…Wong et al recommended coagulation factor replacement at a higher level for a longer period than in the current World Hemophilia Foundation guidelines. It is possible that the prevalence of bleeding may have been decreased if we had used a high coagulation factor replacement regime, maintaining a 100% level of coagulation factor throughout the first 3 weeks following TKA …”

Continuous Infusion of Coagulation Products in Hemophilia

“…The Japanese guideline for hemophilia treatment suggest to use CI for major surgery [35,36]. Many reports demonstrated CI to be safe and hemostatically effective for all indications mentioned above, including the most demanding surgical procedures [1,2,[4][5][6][7]20,[34][35][36][37][38]. Most recently Takedani [37], Rahmé et al [38], and Chevalier et al [39] reported on successful use of CI in 28, 20, and 72 total knee replacements, respectively.…”

“…Many reports demonstrated CI to be safe and hemostatically effective for all indications mentioned above, including the most demanding surgical procedures [1,2,[4][5][6][7]20,[34][35][36][37][38]. Most recently Takedani [37], Rahmé et al [38], and Chevalier et al [39] reported on successful use of CI in 28, 20, and 72 total knee replacements, respectively. A prospective controlled study comparing CI and BI for major surgery using protocols that were similar regarding the surgical technique and postoperative target minimum levels demonstrated that efficacy and safety were better with CI than with BI in terms of minimum factor levels achieved, blood loss (as measured by a decrease in hemoglobin level), blood transfusion requirements, and bleeding complications ( [24].…”