Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States

Tang, Li; Paonessa, Joseph D.; Zhang, Yuesheng; Ambrosone, Christine B.; McCann, Susan E.

doi:10.1016/j.jff.2013.07.011

Cited by 64 publications

(52 citation statements)

References 34 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the glucosinolates glucoraphanin and phenethyl glucosinolate have well-established anticarcinogenic properties, this broad selection against all glucosinolates might be counterproductive. Similarly, the work of Tang et al, 64 who used the benzene dithiol reagent to measure the sum of all isothiocyanates, cannot discriminate between profiles with or without high concentrations of goitrin or sulforaphane.…”

Section: Progoitrin Concentrations That Results In Decreased Thyroid Hmentioning

confidence: 98%

Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

2016

View full text Add to dashboard Cite

Brassica vegetables are common components of the diet and have beneficial as well as potentially adverse health effects. Following enzymatic breakdown, some glucosinolates in brassica vegetables produce sulforaphane, phenethyl, and indolylic isothiocyanates that possess anticarcinogenic activity. In contrast, progoitrin and indolylic glucosinolates degrade to goitrin and thiocyanate, respectively, and may decrease thyroid hormone production. Radioiodine uptake to the thyroid is inhibited by 194 lmol of goitrin, but not by 77 lmol of goitrin. Collards, Brussels sprouts, and some Russian kale (Brassica napus) contain sufficient goitrin to potentially decrease iodine uptake by the thyroid. However, turnip tops, commercial broccoli, broccoli rabe, and kale belonging to Brassica oleracae contain less than 10 lmol of goitrin per 100-g serving and can be considered of minimal risk. Using sulforaphane plasma levels following glucoraphanin ingestion as a surrogate for thiocyanate plasma concentrations after indole glucosinolate ingestion, the maximum thiocyanate contribution from indole glucosinolate degradation is estimated to be 10 lM, which is significantly lower than background plasma thiocyanate concentrations (40-69 lM). Thiocyanate generated from consumption of indole glucosinolate can be assumed to have minimal adverse risks for thyroid health.

show abstract

Section: Progoitrin Concentrations That Results In Decreased Thyroid Hmentioning

confidence: 98%

Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

2016

View full text Add to dashboard Cite

show abstract

“…Cruciferous vegetables contain bioactive precursor compounds known as glucosinolates (Table 1). [15][16][17][18][19] Major glucosinolates are glucobrassicin and glucoraphanin, the latter of which is a derivative of isothiocyanates, 20 including sulforaphane. The average human consumption of glucosinolates from food sources is estimated at 0.5lM/ kg/d.…”

Section: Metabolism Of Diindolylmethane From Indole-3-carbinolmentioning

confidence: 99%

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

Thomson

Ström

2016

Nutr Rev

View full text Add to dashboard Cite

Diet is a modifiable factor associated with the risk of several cancers, with convincing evidence showing a link between diet and breast cancer. The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer chemoprevention. This review focuses on 3,3 0 -diindolylmethane (DIM), the major bioactive indole in crucifers. Research of the cancerpreventive activity of DIM has yielded basic mechanistic, animal, and human trial data. Further, this body of evidence is largely supported by observational studies. Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. This review describes current evidence related to the metabolism and mechanisms of DIM involved in the prevention of breast cancer. Importantly, this review also focuses on current evidence from human observational and intervention trials that have contributed to a greater understanding of exposure estimates that will inform recommendations for DIM intake.

show abstract

“…For example, total glucosinolate content in garden cress and Pe-tsai Chinese cabbage are 389 mg and 20 mg per 100 g fresh weight [50]. The average level of total ITC content ranges from 1.5 µmol per 100 g fresh cauliflower to 61.3 µmol per 100 g mustard greens [51]. …”

Section: Itcs and Cruciferous Vegetablesmentioning

confidence: 99%

Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer

et al. 2015

Self Cite

View full text Add to dashboard Cite

Approximately 80% of human bladder cancers (BC) are non-muscle invasive when first diagnosed and are usually treated by transurethral tumor resection. But 50–80% of patients experience cancer recurrence. Agents for prevention of primary BC have yet to be identified. Existing prophylactics against BC recurrence, e.g., Bacillus Calmette-Guerin (BCG), have limited efficacy and utility; they engender significant side effects and require urethral catheterization. Many cruciferous vegetables, rich sources of isothiocyanates (ITCs), are commonly consumed by humans. Many ITCs possess promising chemopreventive activities against BC and its recurrence. Moreover, orally ingested ITCs are selectively delivered to bladder via urinary excretion. This review is focused on urinary delivery of ITCs to the bladder, their cellular uptake, their chemopreventive activities in preclinical and epidemiological studies that are particularly relevant to prevention of BC recurrence and progression, and their chemopreventive mechanisms in BC cells and tissues.

show abstract

Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States

Cited by 64 publications

References 34 publications

Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer

Contact Info

Product

Resources

About