Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status

Kasvosve, Ishmael; Delanghe, Joris

doi:10.1515/cclm.2002.176

Cited by 54 publications

(42 citation statements)

References 38 publications

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“…Routine investigation for anaemia in Nigeria and subsaharan Africa is by examination of blood film pictures, packed cell volume and haemoglobin concentration except in some Health institutions where facility and personnel is available, additional test for iron markers are added. It has been suggested that for meaningful interpretation of iron status in human, the following iron markers are of importance: haemoglobin, PCV, serum iron, TIBC, UIBC and percent transferri saturation (Kasvosve & Delanghe, 2002;Yamanishi et al, 2003;Nwafia et al, 2006;AACC, 2009). In our earlier study, we relied on serum iron and PCV to define the iron status of HIV infected participants (Onyenekwe et al, 2008;Ukibe et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

Chinedum¹,

Chidiebere²,

Adamma³

et al. 2011

International Journal of Biological and Chemical Sciences

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HIV and malaria co-infections affect iron status. The present study was designed to determine the collective predictive power of some iron markers in HIV infected and malaria co-infected participants. For this study, 101 participants were randomly recruited from indivividuals requesting for HIV screening. The participants were grouped as 'asymptomatic HIV participants (n=36); asymptomatic HIV-malaria co-infected participants (n=19); symptomatic HIV participants (n=16) and HIV uninfected control participants (n=30). Blood analysis were performed for HIV infection, malaria infection, haemoglobin (g/dl), CD4 + T cell count (/mm 3 ), albumin (g/l), iron (ug/dl), UIBC (ug/dl), TIBC (ug/dl) and percent transferrin saturation (TS%). The analysis of variance (ANOVA) showed that the blood concentrations of haemoglobin (f=4.805, p<0.01), iron (f=32.368, p<0.01), TIBC (f= 20.467, p<0.01), TS% (f=7.616, p<0.01) and albumin (f=16.150, p<0.01), were significantly different amongst the groups. The serum albumin, iron, TIBC and TS% were significantly lowered in asymptomatic HIV, asymptomatic HIV-malaria co-infected and symptomatic HIV participants compared respectively with corresponding parameter in the control participants (p<0.01). The CD4 + T cell count was significantly lowered in symptomatic HIV participants compared with asymptomatic HIV participants with or without malaria co-infection (p<0.01). The study suggests that iron status may be affected in HIV infected individuals. The implications of the result are discussed.

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Section: Introductionmentioning

confidence: 99%

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

Chinedum¹,

Chidiebere²,

Adamma³

et al. 2011

International Journal of Biological and Chemical Sciences

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“…LCMV has been proposed to use a receptor in addition to α-dystroglycan 11 , but no enhancement of LCMV pseudovirus entry was observed in the presence of human TfR1, indicating that this alternative receptor is not human TfR1. Transferrin is present at micromolar concentrations in human plasma 13 . We investigated whether iron-bound (holo) transferrin, which binds TfR1 with high affinity, or apo-transferrin, which does not, could modulate the infection of MACV pseudoviruses.…”

mentioning

confidence: 99%

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Radoshitzky

Abraham

Spiropoulou

et al. 2007

Nature

392

436

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At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor α-dystroglycan to infect cells 1 . Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use α-dystroglycan 2 . Here we show a specific, high-affinity association between transferrin receptor 1 (TfR1) and the entry glycoprotein (GP) of Machupo virus. Expression of human TfR1, but not human transferrin receptor 2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the GP of Machupo, Guanarito and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TfR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin and Sabia viruses, but not that of Lassa virus. Iron depletion of culture medium enhanced, and iron supplementation decreased, the efficiency of infection by Junin and Machupo but not Lassa pseudoviruses. These data indicate that TfR1 is a cellular receptor for New World haemorrhagic fever arenaviruses.Arenaviruses are enveloped, single-stranded, bisegmented RNA viruses 3 . The family Arenaviridae consists of a single genus (Arenavirus), which includes at least 23 recognized viruses 4 . Arenaviruses have been classified into two antigenically and geographically distinct groups, the Lassa-lymphocytic choriomeningitis serocomplex ('Old World arenaviruses') and the Tacaribe serocomplex ('New World arenaviruses'). Five arenaviruses are known to cause acute viral haemorrhagic fever in humans, with case-fatality rates as high as 30%. Lassa virus (LASV) is an Old World arenavirus that causes Lassa fever.

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“…However, Tf levels are also influenced by other factors not related to iron kinetics, such as inflammation, infection, malignancy, chronic liver disease, nephrotic syndrome and malnutrition, which may cause a decrease in the values of transferrin whereas pregnancy and oral contraceptives cause an increase of its serum concentration. 45,46,[50][51][52] …”

Section: Transferrin/total Iron Binding Capacitymentioning

confidence: 99%

Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease

et al. 2016

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Introduction: Anaemia can be considered the most common extra-intestinal manifestation in inflammatory bowel disease. Nevertheless, anaemia is often under-diagnosed and under-treated both in adults and children with inflammatory bowel disease. Herein, we report the consensus statements on the management of anaemia in inflammatory bowel disease developed by the Portuguese Working Group on Inflammatory Bowel Disease (known as Grupo de Estudo da Doença Inflamatória Intestinal - GEDII) to aid clinicians in daily management of inflammatory bowel disease patients. Material and Methods: A comprehensive literature review was conducted in order to prepare consensus statements on the following topics: (1) prevalence and diagnosis of anaemia in inflammatory bowel disease, (2) iron supplementation for the prevention of anaemia in inflammatory bowel disease and (3) treatment of anaemia in inflammatory bowel disease. The final statements for each topic were discussed at a consensus meeting and rated according to the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. Consensus: It was concluded that anaemia has a high incidence and prevalence in inflammatory bowel disease, particularly in those with active disease and hospitalised. Patients with anaemia had decreased quality of life and frequently complained of fatigue. Absolute indications for intravenous therapy should be considered: (1) moderate to severe anaemia (haemoglobin < 10.5 g/dL) or clearly symptomatic anaemia; (2) previous intolerance to oral iron supplements; (3) inappropriate response to oral iron; (4) active severe intestinal disease; (5) need for a quick therapeutic response (e.g. surgery in the short term); (6) concomitant therapy with erythropoiesis-stimulating agent; and (7) patient’s preference.

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Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status

Cited by 54 publications

References 38 publications

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

Serum iron markers in HIV and HIV-malaria infected participants residing in malaria endemic area of South-Eastern Nigeria

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease

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