Total internal reflectance fluorescence (TIRF) biosensor for environmental monitoring of testosterone with commercially available immunochemistry: Antibody characterization, assay development and real sample measurements

Tschmelak, Jens; Kumpf, Michael; Käppel, Nina; Proll, Günther; Gauglitz, Güenter

doi:10.1016/j.talanta.2005.09.048

Cited by 62 publications

(21 citation statements)

References 28 publications

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“…Using competitive immunoassays to measure organic compounds and pesticides in river water, the River Analyzer has detection limits in the pg/mL range in real water samples (Le Blanc et al, 2009;Rodriguez-Mozaz, López De Alda, & Barceló, 2009;Tschmelak, Kumpf, Käppel, Proll, & Gauglitz, 2006;Tschmelak, Proll, & Gauglitz, 2004). The River Analyzer design has been integrated into the AWACSS for online, completely automated, unattended, and networked surveillance operations in river environments (Tschmelak et al, 2005c).…”

Section: River Analyzer/automated Water Analyzer Computer Supported Smentioning

confidence: 99%

Total internal reflection fluorescence (TIRF) array biosensors for biothreat agents for food safety and food defense

Taitt¹,

North²

2015

High Throughput Screening for Food Safety Assessment

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Section: River Analyzer/automated Water Analyzer Computer Supported Smentioning

confidence: 99%

Total internal reflection fluorescence (TIRF) array biosensors for biothreat agents for food safety and food defense

Taitt¹,

North²

2015

High Throughput Screening for Food Safety Assessment

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“…A biosensor combining a quartz crystal microbalance the hormone-binding domain of the α-oestrogen receptor (Carmon et al ., 2005) and one based on the combination of immobilization of that receptor with cyclic voltammetry and impedance spectroscopy (Xia et al ., 2010) show promise for the direct detection of oestrogenic compounds. A biosensor based on a commercially available antibody was developed to detect sub-nanogram per litre concentrations of testosterone in environmental water samples, and was incorporated in to the RIANA array of biosensors (Tschmelak et al ., 2006). With the exception of the latter development, most of the other systems are a long way from in-field or in-situ deployment for monitoring endocrine disruptors in environmental water.…”

Section: Biosensorsmentioning

confidence: 99%

Use of In‐Situ Methods

Greenwood

Mills

Fones

et al. 2011

Chemical Marine Monitoring

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“…For example, the RIANA (RIver ANAlyser) project (Tschmelak et al, 2006), supported by the EU, has been conceptualized, designed, developed, and implemented by the Sensors' Group of the Tubingen University, a group with a long history in sensors and actuators ( Figure 2). Prototype construction and in field implementation gained largely from the involvement of Siemens AG.…”

Section: Emerging Need For Collaborative Network-the Role Of Industrymentioning

confidence: 99%

Innovation in biotechnology: moving from academic research to product development—the case of biosensors

Siontorou

Batzias

2010

Critical Reviews in Biotechnology

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The fast pace of technological change in the biotechnology industry and the market demands require continuous innovation, which, owing to the science base of the sector, derives from academic research through a transformation process that converts science-oriented knowledge to marketable products. There appear to be some inherent difficulties in transforming directly the knowledge output of academic research to industrial use. The purpose of this article is to examine certain transition mechanisms from monodisciplinary academic isolation (curiosity-driven and internal-worth innovation) to university-industry alliances (market-driven and public-worth innovation) through inter-organizational multidisciplinary collaboration and contextualize the analysis with the case of biosensors. While the majority of literature on the subject studies the channels of knowledge transfer as determinants of alliance success (transferor/transferee interactions), either from the university side (science base) or the industry side (market base), this article focuses on the transferable (technology base) and how it can be strategically modeled and managed by the industry to promote innovation. Based on the valuable lessons learnt from the biosensor paradigm, the authors argue that strategic industry choices deal primarily with the best stage/point to intersect and seize the university output, implanting the required element of marketability that will transform an idea to a viable application. The authors present a methodological approach for accelerating the knowledge transfer from the university to industry aiming at the effective transition of science to products through a business model reconfiguration.

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Total internal reflectance fluorescence (TIRF) biosensor for environmental monitoring of testosterone with commercially available immunochemistry: Antibody characterization, assay development and real sample measurements

Cited by 62 publications

References 28 publications

Total internal reflection fluorescence (TIRF) array biosensors for biothreat agents for food safety and food defense

Total internal reflection fluorescence (TIRF) array biosensors for biothreat agents for food safety and food defense

Use of In‐Situ Methods

Innovation in biotechnology: moving from academic research to product development—the case of biosensors

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