Total/high density lipoprotein cholesterol and cardiovascular disease (re)hospitalization nadir in type 2 diabetes

Abstract

Modelling showed nonlinear relationships between TC/HDL and risks of CVD hospitalisation and re-hospitalisation consistently in both cohorts (all P < 0.001 for linear tests). The lowest risks of CVD hospitalisation and re-hospitalisation were consistently found for TC/HDL at 2.8 (95% confidence interval: 2.6 to 3.0) in both cohorts and both overall and by gender. This is lower than the current lipid control target, 4.0 of TC/HDL.Reducing the TC/HDL target to 2.8 would include a further 33-44% patients with TC/HDL in the 2.8-4.0 range. Studies are required to assess the effectiveness and cost effectiveness of the earlier introduction of, and more intensive, lipid lowering treatment needed to achieve this new lower TC/HDL target.

Ring finger protein 5 activates sterol regulatory element–binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP

“…Cholesterol is a crucial component of cellular membranes and serves as a precursor of steroid hormones and bile acids (1)(2)(3). Despite being a life-sustaining molecule, a high level of cholesterol in blood has also been linked to cardiovascular diseases (4). Hence, to maintain a delicate cholesterol balance, mammalian cells have evolved an intricate feedback mechanism featuring sterol regulatory element-binding protein 2 (SREBP2) 3 and its sterol-sensing chaperone, SCAP (5,27).…”

Facts Revealed; Total/High Density Lipoprotein Cholesterol Values and Their Ratio Among Macro-Vascular Complications of Diabetes

“…This was lower with said ratio in the 2.8-4.0 range. 20 The majority of prior research had shown affirmative judgment while a few had questionable results as well. Iqbal and coworkers concluded that diabetes appeared to express no distinctive impact on levels of lipoproteins among cardiac patients.…”

Rumex japonicus Houtt. Ethanol Extract and Its Active Component on Prevention of Dyslipidemia and Hyperglycemia in Diet-Induced C57BL/6J Obese Mice

“…The RU supplement also tended to elevate HDL-C level compared to HFD mice. Previous studies have suggested that an elevated HTR combined with TG is associated with high coronary heart disease (CHD) risk [12,13]. Moreover, the apo B/apo A-I ratio was also markedly linked with the risk of CHD, even when the levels of other lipids were within normal ranges, and the apo B/apo A-I ratio was a superior predictor of CHD risk compared to the HTR [14][15][16][17].…”