Total fluoride content of human serum

Singer, Leon; Armstrong, W. D.

doi:10.1016/0003-9969(69)90207-6

Cited by 41 publications

(3 citation statements)

References 12 publications

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“…Thermal power plant workers may be exposed to high levels of cryolite in the air if their work involves certain machinery; in addition, workers in air transportation, medical and other health services, textile and metal manufacturing, or petroleum and coal production may be exposed to fluoride [15] – [19] . Workers in these types of jobs may breathe in levels as high as 2.5 milligrams of fluoride per cubic meter (mg/ \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text{m}^{3})$ \end{document} of air.…”

Section: Introductionmentioning

confidence: 99%

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode

Pandey

Kumar

Yadav

et al. 2015

IEEE J. Transl. Eng. Health Med.

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This study was conducted to analyze the impact of fluoride in the anthropogenic condition in an industrial region promoting and affecting the health of the workers. Fluoride is toxic to humans in high concentrations, such as can occur in persons working in fluoride-containing mineral industries like aluminum industries. When workers are exposed to fluoride-containing minerals, they can suffer from a variety of health problems, such as dental disease. This paper presents the relationship of different clinical conditions correlated against the fluoride level. Contributing clinical aspects, such as morbidity, dysentery, overcrowding, and skin disease, are also studied to assess the consequences of fluoride upon consistent exposure. The relationship between pH and hardness of water with fluoride was measured, and then spatial maps were generated. The investigations resulted in a conclusion that hardness of water had a more pronounced impact on the level of fluoride concentration as compared with pH. Water with more hardness contains more fluoride concentration (25 mg/ml) as compared with soft water (4 mg/ml). This paper also revealed the concentration of fluoride content in the bodies of aluminum plant workers, which varied from 0.06 to 0.17 mg/L of blood serum in the case of pot room workers and 0.01 to 0.04 mg/L in the case of non-pot room workers. In fingernails, it varied from 0.09 to 3.77 mg/L and 0.39 to 1.15 mg/L in the case of pot room and non-pot room workers, respectively. In urine, it varied from 0.53 to 9.50 mg/L in pot room workers and 0.29 to 1.80 mg/L in non-pot room workers. This paper concluded that water was safe for drinking purposes if it has a low hardness (60–140 mg/ml) and pH (7.1–7.4).

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Section: Introductionmentioning

confidence: 99%

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode

Pandey

Kumar

Yadav

et al. 2015

IEEE J. Transl. Eng. Health Med.

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“…Monitoring serum F of patients has been recommended (1) to avoid toxic levels of the anion. Serum F is composed by two fractions: diffusible and protein-bound (2)(3)(4)(5). Diffusible F has mitogenic activity on osteoblasts (6) and is assumed to be responsible for the increase in bone mass produced by chronic administration of F.…”

Section: Introductionmentioning

confidence: 99%

Measurement of total and diffusible serum fluoride

Rigalli¹,

Alloatti²,

Puche³

1999

J. Clin. Lab. Anal.

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This article describes a technique for the measurement of total and diffusible F content of serum, at clinical significant concentrations of F (1-10 microM). The proposed procedure avoids the interference of unknown serum components with the ion-specific electrode. Sample F is concentrated fivefold through distillation of hydrofluoric acid (Taves' method). Ionic fluoride is presented to the electrode in a simple solution at concentrations within the linear response of the electrode. Average recoveries of F from serum or its ultrafiltrate were 96+/-7% (21%) and 97+/-12% (53%) (mean+/-SEM [CV]), respectively. With four replicates of each sample, the technique produce within-run standard deviations of 0.6 microM and 2.2 microM at 1 and 10 microM F, respectively. Total precision assessment gave standard deviations of 0.6 microM and 2.6 microM at 1 and 10 microM F, respectively. The fasting serum F levels of normal climacteric women, 45 to 65 years, showed an asymmetric distribution. The data obtained started at the detection limit of the technique (0.1 mM). The 75 percentile was 1.85 microM for total and 0.5 microM for diffusible F. In patients (n = 25) treated with NaF (30 mg F/day) the fasting levels of total serum F (4.5 +/-1.7 microM) did not differ from those of diffusible F (4.2+/-1.5 microM). In patients (n = 50) treated with sodium monofluorophosphate (15 mg F/day) the fasting levels of total and diffusible serum F were 6.5+/-1.7 microM and 0.5+/-0.03 microM, respectively. In conclusion, this paper establishes the presence of two fractions of serum fluorine: diffusible and nondiffusible (or protein bound) and describes a technique for their clinical estimation. In untreated subjects and in patients receiving NaF, the former fraction contains ionic fluoride. In patients treated with MFP, diffusible serum fluorine is composed by ionic fluoride and low molecular weight, peptide-bound, acid-labile fluorine.

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“…Recent work with improved analytical methods [Taves, 1966[Taves, , 1968Cox and Backer D irks, 1968;Singer and Armstrong, 1969;F ry and T aves, 1970] has established that the concentration of fluoride ion in plasma is generally very low, between 0.01 and 0.10 ppm (< 5 /<m/1). Up to 90% of the fluoride in human plasma is bound as high-molecular weight compounds [Taves, 1971], The fluoride concentration of milk and saliva is of the same magnitude as the ionized fluoride of plasma [Gr0n et al, 1968;E ricsson, 1969;Y ao and G r0n , 1970].…”

Section: Recent Data and Theories Which Support Or Challenge The Safementioning

confidence: 99%

Report on the Safety of Drinking Water Fluoridation

Ericsson¹

1974

Caries Res

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Total fluoride content of human serum

Cited by 41 publications

References 12 publications

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode

Measurement of total and diffusible serum fluoride

Report on the Safety of Drinking Water Fluoridation

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Total fluoride content of human serum

Cited by 41 publications

References 12 publications

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F−Ion-Selective Electrode

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F−Ion-Selective Electrode

Measurement of total and diffusible serum fluoride

Report on the Safety of Drinking Water Fluoridation

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Product

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Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode

Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F⁻Ion-Selective Electrode