Total fluid consumption and risk of bladder cancer: a meta-analysis with updated data

Abstract

With meta-analysis we tented to reveal the potential relationship between daily fluid consumption and bladder cancer risk, and to find out a recommendation on daily fluid intake. Databases of the Web of Science, PubMed and EMBASE were searched then 21 case-control and 5 cohort studies were included. Stratified analyses on gender, region, time of subjects recruiting and fluid quantity were performed as well as dose-response meta-analysis. Comparing the highest exposure category with the lowest in each study, no association appeared when all data pooled together (p=0.50), but a significant OR of 1.46 (1.02-2.08, p=0.04) was found in male subgroup. For different regions, the summarized OR was 1.44 (1.10-1.89) in American case-control studies, 1.87 (1.20-2.90) in European male subgroup and 0.24 (0.10-0.60) in Asia. There was a significant relationship that each increment 1000ml daily consumption would increase the risk by 28.6% in European male (p=0.007). Similarly every additional 1000ml consumption may increase the OR by 14.9% in American people but the association wasn't that strong (p=0.057). Stratified analyses showed fluid consumption over 3000ml/day in American residents and 2000ml/day in European male resulted in OR>1 with statistical significance. In conclusion, a relationship between higher fluid intake and higher bladder cancer risk was observed in European male and American residents and a limitation to <2000ml and <3000ml per day are recommended respectively.

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

“…People who drink a lot of fluids each day, especially water, tend to have lower rates of bladder cancer (1.4 L/day compared with 0.4 L/day) [ 16 , 17 , 18 ]. On the other hand, a meta-analysis confirmed that the high daily fluid intake might be associated with high BC risk in European and American males, and a limitation of fluid consumption to <2000 mL and <3000 mL per day is recommended, respectively [ 19 ]. Bladder cancer occurrence is also associated with age—the median age at diagnosis is 69 years for men and 71 years for women [ 20 ].…”

Total Fluid Intake and the Risk of Recurrence in Patients With Non-Muscle Invasive Bladder Cancer: A Prospective Cohort Study

“…With regard to fluid intake and the risk of developing bladder cancer for the first time, the results of a recent case-control study have shown that there was no association with total water intake from both beverages and foods [ 20 ]. Also the results of a meta-analysis demonstrated no association between total fluid intake and the risk of developing primary bladder cancer [ 21 ]. However, subgroup analyses indicated that high fluid intake could increase the risk of bladder cancer in European men (and possibly American men) and decrease the risk of bladder cancer in Asian men [ 21 ].…”

“…Also the results of a meta-analysis demonstrated no association between total fluid intake and the risk of developing primary bladder cancer [ 21 ]. However, subgroup analyses indicated that high fluid intake could increase the risk of bladder cancer in European men (and possibly American men) and decrease the risk of bladder cancer in Asian men [ 21 ].…”

Hábitos Alimentarios Y Actividad Física en Adultos Mayores Con Enfermedad Crónica

“…Casi la tercera parte señaló tomar 4 vasos de agua natural al día. Al respecto se ha reportado una mínima reducción de enfermedad cardiovascular en los que toman cinco o más vasos de agua diarios (21) y se ha encontrado asociación entre la ingesta total de líquidos y el riesgo de cáncer (22) . También se señala que las recomendaciones del consumo de agua diferente a otros líquidos, no son concluyentes y es diferente en cada persona (23) .…”