Total flavonoids of Flos Chrysanthemi protect arterial endothelial cells against oxidative stress

He, Dongxu; Ru, Xiaochen; Wen, Lei; Yang, Wen; Jiang, Huidi; Bruce, Iain C.; Jin, Jian; Ma, Xin; Xia, Qiang

doi:10.1016/j.jep.2011.10.043

Cited by 50 publications

(32 citation statements)

References 20 publications

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“…Previous studies demonstrated that CFs possessed anti-oxidant, cardiovascular protection [8], anti-inflammation [9], hepato-protection [10], and anticancer [11] effects. Essential oil [12,13], terpenoids [9], flavonoids [14] and caffeoylquinic acids [15] in CFs have been characterized.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Flavonoids from the Flowers of Chuju, a Medical Cultivar of Chrysanthemum Morifolim Ramat

et al. 2018

J. Mex. Chem. Soc.

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Chuju, the flower of Chrysanthemum morifolim cv. Chuju, is a traditional medicine-food material used in China. Bioassay-guided chemical investigation on Chuju led the isolation of 16 flavonoids (1-16) characterized as quercetin (1), isorhamnetin 3-O-β-D-glucoside (2), eriodictyol (3), pyracanthoside (4), apigenin (5), apigetrin (6), acacetin (7), acacipetalin (8), luteolin (9), diosmetin (10), spinacetin (11), axillarin (12), bonanzin (13), cirsiliol (14), chrysosplenol D (15) and artemetin (16). Among them, compounds (11-16) were first reported from the Chrysanthemum species. Chuju flavonoids displayed strong antioxidant in DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical scavenging assay, and high anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cells. These findings suggests that Chuju is an ideal source of natural flavonoids with significant antioxidant and anti-inflammatory effects, and is worthy of further development as health-promoting food or supplement.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Flavonoids from the Flowers of Chuju, a Medical Cultivar of Chrysanthemum Morifolim Ramat

et al. 2018

J. Mex. Chem. Soc.

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“…19 Another study indicated that total flavonoids of Flos chrysanthemi showed vasodilating effects and protected vasodilator reactivity from oxidative stress, which was mediated by endothelium-derived hyperpolarizing factor. 20 Macrophage scavenger receptors take up oxidized low-density lipoprotein to promote cholesterol ester accumulation and foam cell formation, which is another factor contributing to atherosclerotic disease. In animal models, quercetin attenuated atherosclerosis by interfering with foam cell formation and pro-oxidant/proinflammatory response, which were key proatherogenic activities of macrophages.…”

Section: Protective Action On Cardiovascular Diseasesmentioning

confidence: 99%

Phytotherapeutic antioxidants

et al. 2020

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Plants have always been an integrated part of human life, whether we discuss about providing food or we about their medicinal value. Ethnomedicines have led to the discovery of many valuable drugs against various diseases. It has been postulated that most of the disease are related to immune system which is affected by imbalance balance between antioxidants and prooxidants or free radicals. Free radicals are the chemical entities capable of independent existence that contain one/more unpaired electrons and can be balanced by antioxidants. Antioxidants maintain the integrity and function of membrane lipids, cellular proteins, and nucleic acids and the control of signal transduction of gene expression in immune cells. For this reason, the immune cells are particularly sensitive to changes in their antioxidant status. Whenever there is imbalance between prooxidant and antioxidants they can lead to many diseases and even ameliorate the severity of disease like Alzheimer, cardiovascular disorder, cancer etc. There are evidences showing usage of plants as a potent source of antioxidants has provided a lot of support in combating various diseases, without any side effect. Various Bioflavonoids, Carotenoids, Hydroxycinnamates etc helps in scavenging the free radicals and thus proved to be immunostimulant. There are various mechanisms through which these Phyto antioxidants assisted against various disease. The present review is an attempt showing the relationship of free radicals with various diseases and immune system and the role of Phyto antioxidants against various health related conditions.

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“…According to the Chinese Pharmacopoeia, Flos Chrysanthemi could be mainly classified into five varieties 'Hangju', 'Boju', 'Chuju', 'Gongju' and 'Huaiju'. Many pharmacological studies reported that it possesses various functions of antioxidation [1][2][3], cardiovascular protection [4,5], antimicrobial [6] and anti-inflammatory [7,8], which are benefit from the mainly active components, like flavonoids. The variety the 'Hangju' of Flos Chrysanthemi, which has been cultivated for centuries and developed into several genotypes, and the genotype 'Zaoyang' has the largest cultivated area and yield among all the genotypes [9].…”

Section: Introductionmentioning

confidence: 99%

Long-read sequencing of Chrysanthemum morifolium cv. ‘Hangju’ transcriptome reveals flavonoid biosynthesis and regulation

Wang

Yang

et al. 2019

Preprint

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Background : The capitulum of Chrysanthemum morifolium cv. ‘Hangju’ has been widely used in China for antioxidant and anti-inflammatory. Flavonoids as one of the bioactive components in C . morifolium have a poor understanding in their biosynthesis and regulation. Nowadays, transcriptome sequencing as an effective method was used in capturing the transcripts information. So, single-molecule real-time (SMRT) sequencing was performed to obtain the full length of genes involved in flavonoid biosynthesis and regulation in C . morifolium . Results : The high-quality RNA was extracted from the capitulum of C . morifolium at different development stages, and it was constructed into two libraries (0-5 kb and 4.5-10 kb) for sequencing. Finally, 125,532 non-redundant isoforms with mean length of 2,009 bp were captured. Of which, 2,083 transcripts were annotated in the pathway related to the flavonoid biosynthesis and 56 isoforms were annotated as CHS , CHI , F3H , F3’H , FNS Ⅱ , FLS , DFR and ANS genes. Based on the gene expression level at different stages, we predicted the major genes involved in the flavonoid biosynthesis. And we found two candidate MYB factors (CmMYBF1 and CmMYBF2) activating the flavonol biosynthesis by phylogenetic analysis. Conclusions : Based on the full-length transcriptome data and further quantitative analysis, the major genes involved in flavonoid biosynthesis and regulation in C . morifolium were predicted in our study. The results provide a valuable theoretical basis for introduction and cultivation of C. morifolium cv. ‘Hangju’.

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Total flavonoids of Flos Chrysanthemi protect arterial endothelial cells against oxidative stress

Cited by 50 publications

References 20 publications

Antioxidant and Anti-Inflammatory Flavonoids from the Flowers of Chuju, a Medical Cultivar of Chrysanthemum Morifolim Ramat

Antioxidant and Anti-Inflammatory Flavonoids from the Flowers of Chuju, a Medical Cultivar of Chrysanthemum Morifolim Ramat

Phytotherapeutic antioxidants

Long-read sequencing of Chrysanthemum morifolium cv. ‘Hangju’ transcriptome reveals flavonoid biosynthesis and regulation

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