Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice

Zhang, Yili; Jiang, Jun-Jie; Shen, H. F.; Chai, Yan; Xu, Wei; Xie, Yan-Ming

doi:10.2147/dddt.s139804

Cited by 42 publications

(44 citation statements)

References 31 publications

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“…Recently, plant-derived phytochemicals have received attention for their ability to induce osteoblast and osteoclast activity. Phytochemicals with promising therapeutic potential for osteoporosis include isoflavones, stilbenes and flavonoids (7). Icariin (ICA) is a major active flavonoid glycoside extracted from the Chinese herbal medicinal plant Epimedii, and it acts as a phytoestrogen.…”

Section: Introductionmentioning

confidence: 99%

Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling

Peng

Pan

et al. 2018

Mol Med Report

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Icariin (ICA) is a major active ingredient in Herba epimedii, which is commonly used as a Chinese herbal medicine for the treatment of osteoporosis. Previous studies have revealed that ICA exerted a protective effect against bone loss and increased bone regeneration; however, the association between ICA and estrogen receptor (ER) signaling remains unclear. The aim of the present study was to determine the effect of ICA on rat bone marrow stromal cells (rBMSCs). Cell Counting Kit‑8 assays were conducted to measure proliferation, alkaline phosphatase (ALP) activity was evaluated to assess osteoblast differentiation, and reverse transcription‑quantitative polymerase chain reaction as well as western blotting were performed to detect the expression of cellular and molecular markers of osteogenic or adipogenic differentiation. The results demonstrated that treatment of rBMSCs with 10‑6 M ICA stimulated rBMSC proliferation and ALP activity. Furthermore, ICA treatment increased the expression of the osteogenic markers runt‑related transcription factor 2, collagen type 1 and bone morphogenetic Protein 2; however, it also decreased the expression of the adipogenic differentiation markers peroxisome proliferator‑activated receptor gamma and CCAAT/enhancer‑binding protein α. Treatment of rBMSCs with ICI182780, an ER antagonist, blocked the effects of ICA. Taken together, these findings indicated that ICA may stimulate osteoblast differentiation and inhibit adipogenic differentiation via the activation of the ER signaling pathway. Therefore, ICA has the potential to serve as a therapeutic alternative for the prevention and treatment of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling

Peng

Pan

et al. 2018

Mol Med Report

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“…In vivo research also indicated that administration of TFRD significantly increased the BMD and mechanical strength and prevented bone loss induced by hindlimb unloading in rats ( Song et al., 2017 ). Furthermore, clinical practice have proved that TFRD has therapeutic effect on osteoporotic fractures by improving BMD ( Zhang et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens

Huang

Tong

et al. 2020

Poultry Science

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Caged layer osteoporosis ( CLO ) is a common bone metabolism diseases and poses a great threat to the production of laying hens. So far, there is no effective nutrition intervention to prevent CLO. The objective of this study was to evaluate the effects of dietary total flavonoids from Rhizoma Drynariae ( TFRD ), a Chinese herbal, on bone health, egg quality, and serum antioxidant capacity of caged laying hens. A total of two hundred sixteen, 54-wk-old Lohmann Pink-shell laying hens at were allocated to 3 groups with 6 replicates of 12 hens per replicate. The control group was fed a basal diet ( BD ) and 2 treatment groups additionally supplied with 0.5 or 2.0 g/kg TFRD, respectively. Results showed that supplying 2.0 g/kg TFRD enhanced the activities of serum total antioxidant capacity ( P < 0.01) and glutathione peroxidase ( P < 0.05) and had higher femur and tibia bone mineral density (both P < 0.05) compared with the control group. Dietary 2.0 g/kg TFRD also reduced the activities of serum alkaline phosphatase ( P < 0.01), tartrate resistant acid phosphatase ( P < 0.01), and the contents of osteocalcin ( P < 0.01). Furthermore, tibia histomorphology observation showed that the microstructure of bone tissue was improved after TFRD treatment. Egg quality was not affected by TFRD while the egg weight significantly increased ( P < 0.01). These findings suggested that TFRD has beneficial effects on bone health in older caged laying hens.

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“…Previous studies have demonstrated that TFRD can effectively regulate osteogenesis and osteoclastrelated pathways [12]. RUNX2 is a transcription factor that belongs to the Runx family, and has been shown to be essential for osteoblast differentiation and bone formation [35].…”

Section: Discussionmentioning

confidence: 99%

“…Total flavonoids from Rhizoma Drynariae (TFRD), a Chinese herbal product extracted from the dried root of Rhizoma Drynariae, has been developed into a postmarketing Chinese medicine called Qianggu capsule [11]. TFRD has shown good therapeutic effects on osteoporosis in human and animal models [12]. The active monomer composition of TFRD include naringin, naringenin, and neoeriocitrin [13].…”

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confidence: 99%

Total flavonoids of Chinese herb Rhizoma Drynariae alleviates bone loss in caged laying hens

Huang

Tong

et al. 2020

Preprint

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Background: Caged layer osteoporosis (CLO) is a common bone metabolic disease and is threatening the modern poultry industry. The objective of this study was to evaluate effects of total flavonoids of Rhizoma Drynariae (TFRD), a Chinese herbal extract, on bone health, egg quality and production performance in caged laying hens. Totals of 144 Lohmann pink-shell laying hens of 32-wk-old were randomly allocated to 4 groups. The control (CON) group was fed a basal diet, the low calcium diet (LCD) group was fed a low calcium diet, and the TFRD1 and TFRD2 groups were fed LCD supplemented with 0.5 and 2.0 g/kg TFRD, respectively. The experiment lasted 9 wks. Results: Supplying 2.0 g/kg TFRD produced protective effects on calcium deficiency-induced bone loss in caged laying hens, including enhanced femur bone mineral density (P < 0.05), improved bone microarchitecture deterioration, reduced serum levels of alkaline phosphatase and tartrate resistant acid phosphatase activities (both P < 0.05) and osteocalcin content (P < 0.05), down-regulated mRNA expressions of receptor activator of nuclear factor kappa-B ligand (RANKL) (P < 0.01) and up-regulated runt related transcription factor 2 (RUNX2) and osteoprotegerin (OPG) levels (both P < 0.01). Furthermore, compared to LCD group, 2.0 g/kg TFRD treatment had lower malondialdehyd levels (P < 0.01), and higher total antioxidant capacity (P < 0.05) and glutathione peroxidase (P < 0.05) activities, which contributed to the protective effects of bone loss. TFRD supplementation did not affect egg quality while 2.0 g/kg TFRD treatment improved laying rate (P < 0.05) and decreased feed conversion ratio (P < 0.05). Conclusions: These findings suggested that TFRD has beneficial effects on bone health and production performance in caged laying hens, which can be used for the prevention of CLO.

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Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice

Cited by 42 publications

References 31 publications

Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling

Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling

Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens

Total flavonoids of Chinese herb Rhizoma Drynariae alleviates bone loss in caged laying hens

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