Total daily physical activity and the risk of AD and cognitive decline in older adults

Abstract

A higher level of total daily physical activity is associated with a reduced risk of AD.

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

“…Much of the evidence for a beneficial role of exercise in AD patients is associative in nature and based on self-reporting of physical activity levels by participants. Despite this shortcoming, it has been consistently reported that exercise is associated with a reduced risk of dementia and the level of reported physical activity correlates with the incidence of dementia across a number of studies (Andel et al, 2008;Buchman et al, 2012;Larson et al, 2006;Ravaglia et al, 2008). Randomised controlled trials, although few in number, also support exercise as a pro-cognitive intervention in individuals diagnosed with dementia (de Andrade et al, 2013;Kemoun et al, 2010;Van de Winckel et al, 2004;Venturelli et al, 2011;Vreugdenhil et al, 2012).…”

Menschen und Demenz

“…Während Studien, die auf eine direkte pharmakologische Beeinflussung der Demenz zielten, in den letzten Jahren nahezu vollständig enttäuscht haben -so zuletzt bezüg-lich des Antikörpers Solanezumab [3] bieten sich aus der präventiven Perspektive vielversprechende Ansätze. Sowohl epidemiologische Studien als auch Interventionsstudien zeigten auf, dass sich Bewegung und ein gezieltes Kraft-und Ausdauertraining im mittleren Erwachsenenalter positiv auf die Kognition im Alter auswirken [4,5] und auch die Wahrscheinlichkeit, an einer Demenz zu erkranken, senken [6,7]. Wenn bereits ein "mild cognitive impairment" [8] oder eine Demenz [9] Noch befinden wir uns erst am Anfang in unserem Bestreben, Menschen mit Demenz in ihrem jeweiligen Umfeld angemessen zu begegnen.…”

The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

“…54 Furthermore, it is well established that CVRF-reducing lifestyle habits during early and mid-adulthood, including physical exercise and dieting, may reduce the risk of cognitive deficits and AD later in life. [56][57][58] Moreover, several studies have indicated that cognitive impairment may be present in individuals suffering from other cardiovascular conditions such as congestive heart failure (CHF), [59][60][61] atrial fibrillation (AF), 62,63 and coronary artery disease. [64][65][66] Such cognitive deficits may be reduced by stabilization of the cardiac condition.…”