Total daily energy expenditure and activity level in anorexia nervosa

Casper, Regina C.; Schoeller, Dale A.; Kushner, Robert F.; Hnilicka, Jeanne; Gold, Sarah Trainer

doi:10.1093/ajcn/53.5.1143

Cited by 145 publications

(102 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The drive for activity allows some individuals with AN to engage in excessive exercise. Higher than normal activity levels in AN have been confirmed experimentally (Casper et al 1991;Klein et al 2007;Pirke et al 1991). We have suggested that the drive for activity, restlessness, and the mental alertness during the starvation state represent core symptoms of AN and, therefore, ought to be included as diagnostic criteria (Casper 2006).…”

Section: Symptoms In Anmentioning

confidence: 77%

Relevance of animal models to human eating disorders and obesity

2008

View full text Add to dashboard Cite

Background and rationale This review addresses the role animal models play in contributing to our knowledge about the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the usefulness of animal models in complex biobehavioral familial conditions, such as AN, BN, and obesity, that involve interactions among genetic, physiologic, psychological, and cultural factors. Results and conclusionsThe most promising animal model to mimic AN is the activity-based anorexia rodent model leading to pathological weight loss. The paradigm incorporates reward elements of the drive for activity in the presence of an appetite and allows the use of genetically modified animals. For BN, the sham-feeding preparation in rodents equipped with a gastric fistula appears to be best suited to reproduce the postprandial emesis and the defects in satiety. Animal models that incorporate genes linked to behavior and mood may clarify biobehavioral processes underlying AN and BN. By contrast, a relative abundance of animal models has contributed to our understanding of human obesity. Both environmental and genetic determinants of obesity have been modeled in rodents. Here, we consider single gene mutant obesity models, along with models of obesigenic environmental conditions. The contributions of animal models to obesity research are illustrated by their utility for identifying genes linked to human obesity, for elucidating the pathways that regulate body weight and for the identification of potential therapeutic targets. The utility of these models may be further improved by exploring the impact of experimental manipulations on the behavioral determinants of energy balance.

show abstract

Section: Symptoms In Anmentioning

confidence: 77%

Relevance of animal models to human eating disorders and obesity

2008

View full text Add to dashboard Cite

show abstract

“…Anorexia nervosa (AN) is a psychiatric disorder and is often characterized by extreme hypophagia, obsessive fears of being fat and hyperactivity (Casper et al, 1991;Kron et al, 1978;Walsh and Devlin, 1998). The mechanisms underlying the development of AN are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Hillebrand

Kas

Scheurink

et al. 2006

European Neuropsychopharmacology

View full text Add to dashboard Cite

Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of the MC system might underlie the development and propagation of ABA. Pro-opiomelanocortin (POMC) gene expression is normally decreased during negative energy balance. Strikingly, we found a transient up-regulation of POMC mRNA levels in the arcuate nucleus during the development of ABA, indicating a hyperactive MC system. However, wheel running and food intake were not influenced by treating ABA rats with the competitive antagonist SHU9119. This suggests that agonism of MC receptors by endogenous a-melanocyte-stimulating hormone (a-MSH) levels does not underlie ABA. Instead, treatment with the inverse agonist AgRP did ameliorate signs of ABA. This implies that modulation of constitutive MC receptor activity rather than antagonizing putative a-MSH release contributes to the development and propagation of ABA.

show abstract

“…Patients frequently show excessive exercising and can not avoid being active [1,2]. The activity-based anorexia (ABA) model is used to study anorectic behavior in rodents and serves as an animal model of anorexia nervosa.…”

Section: Introductionmentioning

confidence: 99%

Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia

Hillebrand

Rijke

Brakkee

et al. 2005

Physiology & Behavior

View full text Add to dashboard Cite

Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa. In ABA, scheduled feeding in combination with voluntary wheel running leads to hyperactivity, reduced food intake, severe body weight loss and hypothermia. In this study it was investigated whether hyperactivity in ABA could be reduced by introducing a warm plate (which was voluntary accessible and did not influence ambient temperature) into a part of the cage.In ad libitum fed rats, the presence of the warm plate did not influence body temperature, running wheel activity (RWA), body weight or food intake. During ABA, however, rats preferred the warm plate and hypothermia was prevented, while hyperactivity and body weight loss were significantly reduced when compared to ABA rats without a plate. Correlation analysis revealed a significant association between basal body temperature and RWA during the light phase in ABA rats. However, there was no evidence that initiation of light phase RWA was a result of hypothermia. These data suggest that ABA rats prefer to prevent hypothermia passively by choosing a warm plate rather than actively regulating body temperature by hyperactivity. D

show abstract

Total daily energy expenditure and activity level in anorexia nervosa

Cited by 145 publications

References 32 publications

Relevance of animal models to human eating disorders and obesity

Relevance of animal models to human eating disorders and obesity

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia

Contact Info

Product

Resources

About