Total cholesterol content of erythrocyte membranes levels are associated with the presence of acute coronary syndrome and high sensitivity C-reactive protein

Yu, Mei-mei; Yan, Xu; Zhang, Jianhua; Wang, Changhui; Wang, Xiaochen; Zhang, Cheng; Xu, Biao

doi:10.1016/j.ijcard.2009.04.018

Cited by 12 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in agreement with previous studies showing positive correlations between CEM levels and the number of diseased coronary arteries [7, 24]. These results are not in agreement with those of Tziakas et al [16] and Yu et al [25], who concluded that CEM could be a marker of ACS but not of atherosclerosis.…”

Section: Discussionsupporting

confidence: 85%

Association of the Total Cholesterol Content of Erythrocyte Membranes with the Severity of Disease in Stable Coronary Artery Disease

et al. 2014

View full text Add to dashboard Cite

Increasing evidence suggests that erythrocytes may participate in atherogenesis. We sought to investigate whether the total cholesterol content of erythrocyte membranes (CEM) is significantly different in patients with stable coronary artery disease (CAD) compared to patients with nonsignificant coronary stenosis and determine the correlation between CEM and the severity of coronary stenosis. Methods. The population included 144 patients, undergoing clinically indicated coronary angiography. The severity of coronary stenosis was scored after coronary angiography and patients were divided into two groups; the S-stenosis group (CAD patients, n = 82) had a significant stenosis indicated by coronary angiography and the second group, N-stenosis (n = 62), had nonsignificant coronary stenosis. Lipid parameters were determined by routine laboratory methods. CEM was measured using an enzymatic assay, and protein content was assessed by the modified Lowry method. Results. The mean of CEM levels was higher (P < 0.001) in stable CAD patients (137.2 µg/mg of membrane protein) compared with N-stenosis patients (110.0 µg/mg of membrane protein). The coronary artery scores were correlated positively with CEM levels (r = 0.296, P < 0.001). Conclusion. CEM levels are positively associated with the severity of CAD, meaning that CEM might contribute to the development of CAD.

show abstract

Section: Discussionsupporting

confidence: 85%

Association of the Total Cholesterol Content of Erythrocyte Membranes with the Severity of Disease in Stable Coronary Artery Disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Remarkably, the highest level of CEM was found in the STEMI group, followed by the NSTEACS, and the SAP groups. These results are not in agreement with those of Tziakas et al (1) and Xu et al (12), who concluded that CEM could be a marker of ACS but not of atherosclerosis. We now propose that CEM levels are higher in patients with STEMI compared to patients with NSTEACS.…”

Section: Discussioncontrasting

confidence: 86%

Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin

Zhong

Tang

Zeng

et al. 2012

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Introduction. Numerous studies suggest that total cholesterol content of erythrocyte membranes (CEM) might play a critical role in atherosclerotic plaque progression and instability. However, the exact role of CEM in atherosclerosis remains obscure. Our study was designed to investigate the association between CEM and the severity of coronary artery disease (CAD), and to assess the effect of rosuvastatin on CEM levels.Methods. CEM levels were assessed in 136 participants, including acute coronary syndrome (ACS) (non-ST-segment elevation ACS (NSTEACS) and ST-segment elevation myocardial infarction (STEMI)), stable angina pectoris (SAP), and controls. The Gensini score was used to estimate the severity of CAD. Additionally, 54 patients with CAD were medicated with rosuvastatin, 5 or 10 mg once daily, and then checked at 6 months.Results. The highest level of CEM was found in the STEMI group, followed by the NSTEACS, the SAP, and the control groups. Gensini score in group IV (CEM > 141.6 μg/mg) was markedly higher compared with group I (CEM ≤77.6 μg/mg). Gensini scores in group II (77.6 < CEM ≤111.1 μg/mg) and group III (111.1 < CEM ≤141.6 μg/mg) were also higher than in group I (all P < 0.001). Furthermore, a positive correlation was found between CEM levels and Gensini score (r = 0.714, P < 0.001). CEM levels were dose-dependently reduced by rosuvastatin therapy.Conclusions. CEM levels are positively associated with the severity of CAD, meaning that CEM might contribute to the development of CAD. Importantly, rosuvastatin could decrease CEM levels in patients with CAD and might effectively help to attenuate the progression of CAD.

show abstract

“…After the two-year follow-up, the age of all subjects increased and this increase was responsible for the partial raise of hsCRP. Second, hsCRP is a sensitive, nonspecific systemic marker of inflammation and environmental variables, such as lipid levels, blood pressure, obesity and diabetes mellitus can contribute to the variation of hsCRP level [23,24]. Although the change being small, the level of body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol and glucose increased in our study after two-years of follow-up.…”

Section: Discussionmentioning

confidence: 55%

Intra-individual variability of high-sensitivity C-reactive protein in Chinese general population

Jin

et al. 2012

International Journal of Cardiology

View full text Add to dashboard Cite

Total cholesterol content of erythrocyte membranes levels are associated with the presence of acute coronary syndrome and high sensitivity C-reactive protein

Cited by 12 publications

References 7 publications

Association of the Total Cholesterol Content of Erythrocyte Membranes with the Severity of Disease in Stable Coronary Artery Disease

Association of the Total Cholesterol Content of Erythrocyte Membranes with the Severity of Disease in Stable Coronary Artery Disease

Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin

Intra-individual variability of high-sensitivity C-reactive protein in Chinese general population

Contact Info

Product

Resources

About