Total Body Potassium in Relation to Thyroid Hormones and Hyperthyroidism

Edmonds, C. J.; Smith, Tina

doi:10.1042/cs0600311

Cited by 19 publications

(3 citation statements)

References 13 publications

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“…Studies of changes in body composition following treatment for hyperthyroidism are conflicting. Some show that rises in BMI, total fat mass and total lean mass occur in parallel (Zimmerman‐Belsing et al ., 1998; Edmonds & Smith, 1981), others that weight gain after treatment reflects predominantly an increase in muscle and bone mass (Bayley et al ., 1980; De La Rosa et al ., 1997), while another shows that first muscle mass, then adipose tissue but not bone mass is increased (Lönn et al ., 1998). High circulating concentrations of leptin persist after normal body composition has been attained, and this may predispose to weight gain (Zimmerman‐Belsing et al ., 1998).…”

Section: Discussionmentioning

confidence: 99%

Weight gain following treatment of hyperthyroidism

Dale¹,

Daykin²,

Holder

et al. 2001

Clinical Endocrinology

113

104

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Section: Discussionmentioning

confidence: 99%

Weight gain following treatment of hyperthyroidism

Dale¹,

Daykin²,

Holder

et al. 2001

Clinical Endocrinology

113

104

View full text Add to dashboard Cite

show abstract

“…Established body composition evaluation techniques in a previous study showed that the loss of bone mineral content and MM was predominant in typical hyperthyroidism (37). In another study, it was shown that the free-fat mass was more sensitive to thyroid hormones than the body fat mass (38). During treatment, patients who developed hypothyroidism had a larger weight gain than those who did not (6).…”

Section: Discussionmentioning

confidence: 97%

Short-term Change in Resting Energy Expenditure and Body Compositions in Therapeutic Process for Graves' Disease

et al. 2020

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Objective In the medical treatment of Graves' disease, we sometimes encounter patients who gain weight after the onset of the disease. To estimate the energy required during the course of treatment when hyperthyroidism ameliorates, we measured the resting energy expenditure (REE) and body composition in patients with Graves' disease before and during treatment in the short-term. Methods Twenty patients with newly diagnosed Graves' disease were enrolled, and our REE data of 19 healthy volunteers were used. The REE was measured by a metabolic analyzer, and the basal energy expenditure (BEE) was estimated by the Harris-Benedict formula. The body composition, including body weight, fat mass (FM), muscle mass (MM) and lean body mass (LBM), were measured by a multi-frequency body composition analyzer. We tailored the nutritional guidance based on the measured REE. Results Serum thyrotropin levels were significantly increased at three and six months. Serum free thyroxine, free triiodothyronine and REE values were significantly decreased at one, three and six months. The REE/BEE ratio was 1.58±0.28 at the onset and significantly declined to 1.34±0.34, 1.06±0.19 and 1.01±0.16 at 1, 3 and 6 months, respectively. Body weight, MM and LBM significantly increased at three and six months. Conclusion The REE significantly decreased during treatment of Graves' disease. The decline was evident as early as one month after treatment. The REE after treatment was lower than in healthy volunteers, which may lead to weight gain. These data suggest that appropriate nutritional guidance is necessary with shortterm treatment before the body weight normalizes in order to prevent an overweight condition and the emergence of metabolic disorders.

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“…However, the results of studies examining alterations in body composition following treatment for Graves’ disease have been inconsistent. Several previous studies have compared changes in body composition in patients with hyperthyroidism due to Graves’ disease or toxic multinodular goiter pre- and post-treatment with antithyroid drugs (ATD) or radioactive iodine, showing increases in lean mass [ 5 ], fat mass [ 6 ], or both [ 1 , 2 , 7 - 9 ]. Furthermore, these changes in body composition have been reported to occur sequentially (muscle gain followed by fat gain or vice versa) [ 2 , 9 ] or concurrently [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Body Weight and Composition in Patients With Graves’ Disease Treated with Total Thyroidectomy

Fukuda,

Tachibana,

Osako

et al. 2024

Cureus

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Objective: Thyrotoxicosis causes excess energy expenditure, resulting in weight loss, despite increased appetite, and changes in body composition, which are typically reversible with the normalization of thyroid hormone levels. However, patients with hyperthyroidism due to Graves’ disease are sometimes hesitant to undergo treatment because of the perceived morbidity associated with weight gain. Therefore, obtaining data to explain the details of such weight gain to these patients is important. This study aimed to investigate changes in body weight and composition in patients with Graves’ disease after total thyroidectomy. Methods: In total, 21 patients with Graves’ disease who underwent total thyroidectomy were enrolled. Among them, nine patients were hyperthyroid (group A) and 12 were euthyroid (group B, control) immediately before surgery. Body weight, height, and body composition using bioelectrical impedance were measured preoperatively and five months postoperatively. Results: In all patients, body weight, body mass index, and skeletal muscle mass, but not fat mass, significantly increased postoperatively. In individual groups, a significant increase in skeletal muscle and fat masses was observed solely in groups A and B, respectively. Furthermore, a significant positive correlation between preoperative thyroid function and differences in skeletal muscle mass preoperatively and postoperatively was found. Conclusion: Our study shows that the normalization of thyroid function using thyroidectomy in patients with Graves’ disease is accompanied by weight gain, mainly due to an increase in skeletal muscle mass. These data are clinically significant because they enable physicians to explain to patients that weight gain after surgical treatment for Graves’ disease is favorable and reassure them of their concern.

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Total Body Potassium in Relation to Thyroid Hormones and Hyperthyroidism

Cited by 19 publications

References 13 publications

Weight gain following treatment of hyperthyroidism

Weight gain following treatment of hyperthyroidism

Short-term Change in Resting Energy Expenditure and Body Compositions in Therapeutic Process for Graves' Disease

Alterations in Body Weight and Composition in Patients With Graves’ Disease Treated with Total Thyroidectomy

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