Total body metabolism of 13C-octanoic acid is preserved in patients with non-alcoholic steatohepatitis, but differs between women and men

Schneider, A; Kraut, Christine; Lindenthal, Birgit; Braden, Barbara; Caspary, W. F.; Stein, Jürgen M.

doi:10.1097/00042737-200511000-00005

Cited by 29 publications

(38 citation statements)

References 20 publications

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“…Both in vitro and in vivo studies have found no difference in hepatic mitochondrial oxidative capacity between subjects with NAFLD and control subjects, whereas defects in oxidative phosphorylation may be present in nonalcoholic steatohepatitis (NASH) (15)(16)(17)(18)(19). Plasma ketone concentrations have been shown to be higher in subjects with NAFLD and NASH (15), which is indirect evidence of increased hepatic fatty acid oxidation.…”

Section: Discussionmentioning

confidence: 99%

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

Browning¹,

Baker²,

Rogers³

et al. 2011

The American Journal of Clinical Nutrition

268

269

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Section: Discussionmentioning

confidence: 99%

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

Browning¹,

Baker²,

Rogers³

et al. 2011

The American Journal of Clinical Nutrition

268

269

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“…For the 13 C-based breath tests, pitfalls include potential loss of accuracy in patients with other diseases involving the intestinal mucosa, pancreas, liver, and respiratory system. [ 13 C]octanoic acid is absorbed across the mucosa undigested, so it is not dependent on biliary and pancreatic secretions or mucosal enzymes; moreover, the oxidative break- (105,132). [ 13 C]octanoic acidbased GEBT may be affected by diseases reducing the absorptive capacity of the small intestine and advanced pulmonary disease.…”

Section: Stable Isotope Breath Testsmentioning

confidence: 99%

Methods for measurement of gastric motility

Szarka¹,

Camilleri²

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

103

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Szarka LA, Camilleri M. Methods for measurement of gastric motility. Am J Physiol Gastrointest Liver Physiol 296: G461-G475, 2009. First published January 15, 2009 doi:10.1152/ajpgi.90467.2008There is an array of tests available to measure gastric motility. Some tests measure end points, such as gastric emptying, that result from several different functions, whereas other tests are more specific and test only a single parameter, such as contractility. This article reviews the tests most commonly available in practice and research to evaluate in vivo the gastric functions of emptying, accommodation, contractility, and myoelectrical activity. The rationale for testing, the relative strengths and weaknesses of each test, and technical details are summarized. We also briefly indicate the applications and validations of the tests for use in experimental animal studies. contractility; emptying; accommodation; gastroparesis; dyspepsia ASSESSMENT OF THE MOTOR FUNCTIONS (motility) of the stomach is important in studies of gastric physiology and pathophysiology. Although not generally applied in gastroenterological practice, there is increasing use of tests to evaluate gastric function, particularly less invasive tests in clinical settings.There is an array of tests available to measure gastric motility. Some tests measure end points, such as gastric emptying, that result from several different functions, whereas other tests are more specific and test only a single parameter, such as contractility. This article reviews the tests most commonly available in practice and research to evaluate in vivo the gastric functions of emptying, accommodation, contractility, and myoelectrical activity. The rationale for testing, the relative strengths and weaknesses of each test, and technical details are summarized. A brief discussion is also provided for methods that have been used in animals to study motor functions of the stomach in animals. Tests to Evaluate Gastric Emptying of SolidsGastric emptying is a composite end point reflecting a variety of functions including gastric accommodation, the pressure gradient between the proximal and distal stomach, and antropyloroduodenal contractility and coordination. The trituration of solids and emptying of solid and liquid food from the stomach are arguably the most important physiological functions of the stomach. Abnormal gastric emptying, either accelerated at 1 h or delayed at 4 h, is among the factors that contribute to reporting of dyspepsia or the development of postprandial symptoms after meal challenge (35). For all tests of gastric motility and emptying, there are standard precautions (1): 1) Drugs affecting gastric motility (e.g., anticholinergics, narcotics, and prokinetics) are stopped for 48 h prior to the test, and the study is performed in the morning after an overnight fast. 2) Diabetic subjects should have a glucose level Ͻ275 mg/dl. 3) At the time the meal is ingested, Type 1 diabetic patients should receive half of their normal insulin dose. Gastric Emptying Scintigrap...

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“…A recent investigation suggested that the total 13 CO 2 recovery in OBT was about 1·3-fold larger in women than in men [21]. A recent investigation suggested that the total 13 CO 2 recovery in OBT was about 1·3-fold larger in women than in men [21].…”

Section: Discussionmentioning

confidence: 98%