Total Body Irradiation in the Treatment of Chronic Lymphogenous Leukemia

Autologous lymphocytes as vectors to target therapeutic radiation, using indium‐114m, in patients with lymphoid cell malignancy

“…CLL and SLNHL remain incurable diseases despite the fact that the malignant lymphocyte is sensitive to the cytotoxic effect of both radiation and chemotherapy. The use of radiation therapy in these diseases has predominately involved splenic irradiation (Byhardt et al , 1975) and total body irradiation (Del Regato, 1974; Johnson, 1979; Rubin et al , 1981). These approaches have been limited by normal tissue toxicity and currently play only a very restricted part in the treatment of CLL and SLNHL.…”

Low‐dose total body irradiation augments the therapeutic effect of interleukin‐2 in a mouse model for metastatic malignant melanoma

“…Tumor burden in the lungs was estimated using the method described by Nielsen et al. (10) The frozen lungs were sectioned in 8‐μm thick sections making sure that: (1) the first sections were chosen randomly, (2) the distance between the sections were fixed, and (3) the sections were collected from throughout the entire lung. Each of the five histological sections was then systematically scanned frame by frame, using an x200 objective of an Olympus microscope, and digital pictures were taken of the entire section and saved.…”

“…Low‐dose total body irradiation (LTBI) is currently used in the treatment of chronic lymphocytic leukemia (CLL)(2), and low‐grade non‐Hodgkin's lymphoma (NHL)(3). The usual practice is to deliver 0.1 to 0.25 Gy per fraction several times a week until a cumulative dose of approximately 1.5 to 2 Gy is reached.…”

The Complete Spleen

“…More extensive lymphoid irradiation, including total body irradiation (Del Regato, 1974), has been explored during the past quarter-century. These techniques do not appear to be consistently superior to chemotherapy, and are often associated with excessive marrow suppression.…”