Total-body irradiation before bone marrow transplantation for acute leukemia in first or second complete remission

Belkacémi, Yazid; Pene, F.; Touboul, E.; B, Rio; Leblond, Véronique; Gorin, Norbert‐Claude; Laugier, A; Gemici, Cengiz; Housset, M.; Özşahin, Mahmut

doi:10.1007/bf03038482

Cited by 40 publications

(31 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…24 However, thyroid hypofunction was more common in patients who received single fraction TBI, 11,24 similar to the findings in this study. Height was significantly more impaired 3 years after TBI in a single fraction group despite the lower total dose of radiation.…”

Section: Bone Marrow Transplantationsupporting

confidence: 85%

Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission – long-term follow-up

Vaidya

Atra

Bahl

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:From 1984 to 1996, 31 consecutive children without sibling donors, aged 5-19 years (median 8) with acute lymphoblastic leukaemia (ALL) in second complete remission (CR), received unpurged autologous bone marrow transplantation (ABMT) after melphalan and single fraction total body irradiation (TBI). ABMT was performed using fresh unmanipulated marrow harvested after standard reinduction and consolidation therapy 2-11 months (median 5) after relapse. With a median survival of 2.9 years the probability of survival for all patients in continuing second CR was 45.1% (95% CI, 24%-62%) after 5 years. Regimen-related and non-leukaemia mortality was 7% (95% CI, 2%-26%). The longest time to second relapse from ABMT was 3.1 years. Pituitary and gonadal dysfunction requiring hormonal replacement therapy occurred in the majority of long-term survivors. Twelve patients developed cataracts. ABMT with melphalan/single fraction TBI has proved an effective anti-leukaemia treatment with low regimen-related mortality but significant long-term morbidity. The current approach of allogeneic BMT from an unrelated donor when no sibling donor is available, following conditioning with cyclophosphamide/ fractionated TBI has resulted in a reduced relapse rate and improved short-term overall survival in the treatment of relapsed childhood ALL. However, long-term results are awaited. Bone Marrow Transplantation (2000) 25, 599-603. Keywords: childhood ALL; autologous BMT; melphalan/TBI; second remission Childhood acute lymphoblastic leukaemia (ALL) is curable in 60-70% of patients in first complete remission (CR) with first-line therapy. 1,2 However, the outcome of children in second or subsequent CR is much less favourable following second-line therapy with or without bone marrow transplantation (BMT). 3,4 The two most important factors that affect the long-term prognosis post relapse are the site of relapse (bone marrow vs extramedullary sites) and duration of first remission. 3,4 Allogeneic BMT from an HLA-matched sib-

show abstract

Section: Bone Marrow Transplantationsupporting

confidence: 85%

Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission – long-term follow-up

Vaidya

Atra

Bahl

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Nine papers were found with results of one specific TBI scheme [1,3,10,14,18,21,30,33,41] (Table 1). Several studies could not be included because of obscurity of dose rate or number of fractions, abundance of autologous-transplanted patients, or because of a too short follow-up period [6, 13, 15-17, 35, 37, 38, 43].…”

Section: Literature Searchmentioning

confidence: 99%

Biologically Effective Dose in Total-Body Irradiation and Hematopoietic Stem Cell Transplantation

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Werden zwei unabhängige Parameter auf statistische Signifikanz getestet, so steigt das oben genannte 5%-Risiko auf etwa das Doppelte, also 10%, an. Werden n unabhängige statistische Tests durchgeführt, so steigt der Fehler erster Art gemäß der folgenden Formel an: In insgesamt 18 Arbeiten wurde eine multivariate Analyse durchgeführt [6,17,19,32,39,45,62,64,65,77,101,114,138,145,154,155,170,178]. In zwei dieser Arbeiten wurde der Fehler erster Art entsprechend adjustiert [6,178].…”

Section: Statistische Signifikanz Und Der Fehler Erster Artunclassified

Multiple Signifikanztests und ihre Bedeutung bei der Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

Beck‐Bornholdt¹,

Dubben²

2000

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

Total-body irradiation before bone marrow transplantation for acute leukemia in first or second complete remission

Abstract: The outcome of BMT patients conditioned with TBI for acute leukemia was not significantly influenced by the TBI technique, and TRM seemed to be lower in patients treated after 1985. On the other hand, cataract incidence was significantly influenced by the instantaneous dose rate.

Cited by 40 publications

References 58 publications

Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission – long-term follow-up

Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in second remission – long-term follow-up

Biologically Effective Dose in Total-Body Irradiation and Hematopoietic Stem Cell Transplantation

Multiple Signifikanztests und ihre Bedeutung bei der Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

Contact Info

Product

Resources

About