Total body glutathione depletion induces oxidative stress and disrupts the immune function in mice

Abdalla, Maher Y.; Hassan, Iman; Mustafa, Noor H.; Tahtamouni, Lubna H.; Ahmad, Iman M.

doi:10.1080/02772248.2010.494828

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…44,45 GSH is a major intracellular antioxidant tripeptide that plays a critical role in sulfhydryl homeostasis. 46 Under optimal cellular conditions, GSH exists overwhelmingly in the reduced form, owing to the ubiquitous presence of glutathione reductase, which reduces the oxidized form of GSH (GSSG). Changes in GSH homeostasis can be measured by monitoring changes in the ratio of intracellular GSH:GSSG, with a reduction in the ratio indicative of oxidative stress, thus triggering activation of NRF2 (Figure 2).…”

Section: Sulforaphane-induced Modulation Of Oxidative Stressmentioning

confidence: 99%

“…Cellular oxidative stress, which results from an imbalance between rapid generation of reactive oxygen species (ROS) and the ability of the body to detoxify these products, is linked to numerous pathologies, including chronic inflammation, cardiovascular disease and cancer 44,45 . GSH is a major intracellular antioxidant tripeptide that plays a critical role in sulfhydryl homeostasis 46 . Under optimal cellular conditions, GSH exists overwhelmingly in the reduced form, owing to the ubiquitous presence of glutathione reductase, which reduces the oxidized form of GSH (GSSG).…”

Section: Sulforaphane‐induced Modulation Of Oxidative Stressmentioning

confidence: 99%

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Exploring the anti‐inflammatory activity of sulforaphane

Treasure,

Harris,

Williamson

2023

Immunol Cell Biol

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Dysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed. Sulforaphane, a phytochemical derived from plants of the brassica family, is a potent inducer of phase II detoxification enzymes via nuclear factor‐erythroid factor 2–related factor 2 (NRF2) signaling. Moreover, a growing body of evidence suggests additional diverse anti‐inflammatory properties of sulforaphane through interactions with mediators of key signaling pathways and inflammatory cytokines. Multiple studies support a role for sulforaphane as a negative regulator of nuclear factor kappa‐light chain enhancer of activated B cells (NF‐κB) activation and subsequent cytokine release, inflammasome activation and direct regulation of the activity of macrophage migration inhibitory factor. Significantly, studies have also highlighted potential steroid‐sparing activity for sulforaphane, suggesting that it may have potential as an adjunctive therapy for some inflammatory conditions. This review discusses published research on sulforaphane, including proposed mechanisms of action, and poses questions for future studies that might help progress our understanding of the potential clinical applications of this intriguing molecule.

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Section: Sulforaphane-induced Modulation Of Oxidative Stressmentioning

confidence: 99%

Section: Sulforaphane‐induced Modulation Of Oxidative Stressmentioning

confidence: 99%

Exploring the anti‐inflammatory activity of sulforaphane

Treasure,

Harris,

Williamson

2023

Immunol Cell Biol

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“…Glutathione is a tripeptide of three amino acids: glutamic acid, cysteine, and glycine, and it is the most abundant non-protein thiol compound in almost all eukaryotic cells. It has important biological roles, including protection against oxidative stress, control of redox potential, detoxification of toxins, protein folding, and organic sulfur storage and transport [ 10 ], as well as immune reinforcement effects [ 11 , 12 ]. Because of these biological effects, glutathione is used in the food industry as an additive to improve the nutritional value of products.…”

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confidence: 99%

Identification of Wild Yeast Strains and Analysis of Their β-Glucan and Glutathione Levels for Use in Makgeolli Brewing

Kang

Kim

et al. 2014

Mycobiology

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Makgeolli, also known as Takju, is a non-filtered traditional Korean alcoholic beverage that contains various floating matter, including yeast cells, which contributes to its high physiological functionality. In the present study, we assessed the levels of β-glucan and glutathione in various yeast strains isolated from traditional Korean Nuruk and selected a β-glucan- and glutathione-rich yeast strain to add value to Makgeolli by enhancing its physiological functionality through increased levels of these compounds. Yeast β-glucan levels ranged from 6.26% to 32.69% (dry basis) and were strongly species-dependent. Dried Saccharomyces cerevisiae isolated from Nuruk contained 25.53 µg/mg glutathione, 0.70 µg/mg oxidized glutathione, and 11.69 µg/g and 47.85 µg/g spermidine and L-ornithine monohydrochloride, respectively. To produce functional Makgeolli, a β-glucan- and glutathione-rich yeast strain was selected in a screening analysis. Makgeolli fermented with the selected yeast strain contained higher β-glucan and glutathione levels than commercial Makgeolli. Using the selected yeast strain to produce Makgeolli with high β-glucan and glutathione content may enable the production of functional Makgeolli.

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