Total antioxidant/oxidant status in chronic periodontitis patients with type II diabetes following nonsurgical periodontal therapy

Vincent, Ruby Ramya; Appukuttan, Devapriya; Balasundaram, Aruna; Naik, Vanaja Krishna; Victor, Dhayanand John

doi:10.4103/amhs.amhs_12_20

Cited by 3 publications

(6 citation statements)

References 23 publications

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“…However, their study did not include diabetic patients which could stress on the effect of SRP in reducing oxidative stress in periodontitis patients. Also, the results of the present study agreed with those of (Vincent et al, 2020) who examined the effect of non-surgical periodontal treatment on GCF TOS in chronic periodontitis patients with T2DM showing a statistically significant reduction (P < 0.001) at 6 weeks compared to baseline values.…”

Section: Gingival Index (Gi) Scoressupporting

confidence: 91%

“…Several studies were consistent with the results of this clinical trial concerning the enhanced clinical parameters after SRP in diabetic patients as (Agarwal et al, 2016) reported a statistically significant decrease in mean PPD and CAL at 6 months (P < 0.005) after SRP for moderately controlled T2DM patients and chronic periodontitis. Similarly, (Vincent et al, 2020) and (Soi et al, 2021) confirmed a statistically significant decrease in GI, PPD and CAL values after SRP in T2DM patients with chronic periodontitis after 6 weeks and 6 months respectively. On the contrary, (Rodrigues et al, 2003) found no statistically significant changes in mean mm CAL at 3 months after non-surgical periodontal therapy for T2DM patients with periodontitis.…”

Section: Gingival Index (Gi) Scoresmentioning

confidence: 52%

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The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Abdulrab,

Ahmed,

Darhous

et al. 2023

Advanced Dental Journal

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Aim: This study aimed to evaluate the effect of systemic administration of zinc supplementation on the total oxidant capacity in the gingival crevicular fluid level of controlled type 2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.Subjects and Methods: This clinical trial was registered at ClinicalTrials.gov Identifier: ID: NCT03923829 on April 23, 2019. Twenty-eight controlled type 2 diabetic patients with periodontitis stages II or III were randomly assigned into two groups, test and control where both received non-surgical periodontal therapy while the test group received 50 mg zinc one tablet/day for 12 weeks. Total oxidant capacity (TOC) level was measured in GCF of both groups at baseline and after 3 months. HbA1c level, GI, PPD and CAL were also reported at baseline and 3 months postoperatively.Results: After 3 months a statistically significant decrease in mean TOC µmol/L was reported in both groups being more significantly lower in test group. No significant difference in mean percentage HbA1c was reported after 3 months neither within each group nor between the two groups. In both groups there was a significant reduction in GI scores, PPD reduction and CAL gain after 3 months with no significant difference between them, while the test group showed significantly lower GI than the control group. Conclusion:Systemic administration of zinc supplements as an adjunct to non-surgical periodontal therapy might improve the clinical parameters and oxidative stress in T2DM patients with stage II-III periodontitis.

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Section: Gingival Index (Gi) Scoressupporting

confidence: 91%

Section: Gingival Index (Gi) Scoresmentioning

confidence: 52%

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Abdulrab,

Ahmed,

Darhous

et al. 2023

Advanced Dental Journal

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“…Cairan sulkus gingiva merupakan parameter yang paling banyak di teliti. [4][5][6] Peradangan pada jaringan periodontal yang disebabkan oleh bakteri pathogen periodontal memicu terjadinya respon inflamasi dan ditandai dengan adanya aktifitas enzim proteolitik yang kemudian akan terbentuk radikal bebas. 7,8 Radikal bebas merupakan atom atau molekul yang memiliki satu atau lebih elektron yang tidak berpasangan dan memiliki sifat sangat reaktif.…”

Section: Pendahuluanunclassified

“…Gel teh hijau yang sudah terdapat dalam syringe menggunakan ultrasonic scaler. 4,5 Tindakan skeling dan root planing dapat dilakukan bersamaan dengan penambahan agen kemoterapeutik sebagai terapi tambahan dengan tujuan mengontrol flora bakteri, mengurangi peradangan, sebagai antioksidan sehingga mempercepat proses penyembuhan dan kondisi jaringan mengalami perbaikan. Salah satu agen kemoterapeutik yang dapat diaplikasikan dan memiliki kandungan antioksidan adalah catechin yang berasal dari teh hijau dapat membantu mengurangi peradangan serta mempercepat proses penyembuhan jaringan.…”

Section: Pendahuluanunclassified

“…Kadar TAOC dalam cairan sulkus gingiva setelah dilakukan perawatan skeling dan root planing pada penderita periodontitis kronis mengalami peningkatan yang lebih tinggi dibandingkan pada jaringan periodontal sehat akibat danya proses penyembuhan jaringan. 4,5,12,29 Gel teh hijau dalam penelitian ini merupakan hasil ekstraksi daun teh hijau dan bukan hasil purifikasi zat aktif antioksidan yaitu catechin, sehingga memungkinkan kadar antioksidan yang terkandung menjadi lebih sedikit akibat tahapan proses pembuatan dari daun teh hijau menjadi gel. Faktor lain yang dapat mempengaruhi kandungan catechin yaitu jenis proses sebelum pengeringan, jenis teh hijau, persiapan infusi, kondisi pertumbuhan (misalnya tanah, iklim, pertanian, fertilisasi), kondisi geografik.…”

Section: Metodeunclassified

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<p>Pengaruh aplikasi gel teh hijau (Camellia sinensis) terhadap kadar total antioxidant capacity (TAOC) sebagai perawatan tambahan dari skeling dan root planing pada pasien dengan periodontitis kronis</p><p>Effect of green tea (Camellia sinensis) gel application on the total antioxidant capacity (TAOC) levels as adjunct to scaling and root planing in patients with chronic periodontitis</p>

2020

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Pendahuluan: Mekanisme peradangan periodontitis kronis menghasilkan reaksi oksidasi, diketahui melalui kadar total antioxidant capacity (TAOC) cairan sulkus gingiva. Teh hijau dapat menghambat bakteri patogen periodontal sehingga kerusakan jaringan periodontal tidak bertambah parah. Tujuan penelitian adalah menganalisis kadar TAOC sebelum dan sesudah skeling dan root planing disertai gel teh hijau sebagai antioksidan. Metode: Jenis penelitian eksperimen semu, rumus ukuran sampel untuk menguji perbedaan dua rata-rata data tidak berpasangan, setiap subyek memiliki poket ≥ 5 mm, dikelompokkan sisi uji (n=14) dan sisi kontrol (n=14) (split mouth). Pengambilan cairan sulkus gingiva dilakukan pada hari ke-0, 15, dan 30, menggunakan metode absorbing paper strip dengan cara intracrevicular. Kedua sisi dilakukan skeling dan root planing, sisi uji diberikan gel. Hasil: Perbandingan kadar TAOC antara sisi kontrol dan sisi uji pada hari ke-0 (p=0,986), hari ke-15 (p=0,836), dan hari ke-30 (p=0,371) menunjukkan tidak terdapat perbedaan bermakna (p-value>0,05). Perbandingan rerata selisih kadar TAOC dalam kedua kelompok antara hari ke-0 dengan ke-15 (p=0,946), hari ke-0 dengan hari ke-30 (p=0,504), serta hari ke-15 dengan hari ke-30 (p=0,811) jugwa menunjukkan tidak terdapat perbedaan bermakna. Simpulan: Tidak terdapat pengaruh aplikasi gel teh hijau (Camellia sinensis) terhadap kadar total antioxidant capacity (TAOC) pada perawatan periodontitis kronis berupa skeling dan root planing.Kata kunci: Gel teh hijau, periodontitis kronis, skeling dan root planing, total antioxidant capacity (TAOC). ABSTRACTIntroduction: The inflammatory mechanism of chronic periodontitis produces an oxidation reaction, measured through the level of total antioxidant capacity (TAOC) of the gingival crevicular fluid. Green tea can inhibit periodontal pathogenic bacteria so that periodontal tissue damage will not worsen. This study was aimed to analyse the levels of TAOC before and after scaling and root planing with green tea gel as an antioxidant. Methods: The research was quasi-experimental. The sample size formula was used to test the difference between two unpaired data means. Each subject has a pocket ≥ 5 mm, grouped by the test side (n = 14) and the control side (n = 14) (split-mouth). The gingival crevicular fluid was collected on days 0, 15, and 30, using the intracrevicular method with absorbing paper strips. Both sides were treated with scaling and root planing, and the test side was administered with the green tea gel. Results: Comparison of TAOC levels between the control side and the test side on day 0 (p = 0.986), day 15 (p = 0.836), and day 30 (p = 0.371) showed no significant difference (p-value > 0.05). Comparison of the mean difference of the TAOC levels in two groups between day 0 with day 15 was p = 0.946, day 0 with day 30 was p = 0.504, and day 15 with day 30 was p = 0.811; which also showed no significant difference. Conclusion: There is no effect of green tea gel (Camellia sinensis) application on the Total Antioxidant Capacity (TAOC) level in chronic periodontitis treatment in the form of scaling and root planing.Keywords: Green tea gel, chronic periodontitis, scaling and root planing, total antioxidant capacity (TAOC).

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The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Alqawi

Mahmoud

Darhous

et al. 2022

Preprint

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Objectives: This study aimed to evaluate the effect of systemic administration of zinc supplementation on the total oxidant capacity in the gingival crevicular fluid level of controlled type 2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.Materials and Methods: This clinical trial was registered at ClinicalTrials.gov Identifier: ID: NCT03923829 on April 23, 2019. Twenty-eight controlled type 2 diabetic patients with periodontitis stages II or III were randomly assigned into two groups, test and control where both received non-surgical periodontal therapy while the test group received 50 mg zinc one tablet/day for 12 weeks. Total oxidant capacity (TOC) level was measured in GCF of both groups at baseline and after 3 months. HbA1c level, GI, PPD and CAL were also reported at baseline and 3 months postoperatively.Results: After 3 months a statistically significant decrease in mean TOC µmol/L was reported in both groups being more significantly lower in test group. No significant difference in mean percentage HbA1c was reported after 3 months neither within each group nor between the two groups. In both groups there was a significant reduction in GI scores, PPD reduction and CAL gain after 3 months with no significant difference between them, while the test group showed significantly lower GI than the control group.Conclusions: Systemic administration of zinc supplements as an adjunct to non-surgical periodontal therapy might improve the clinical parameters and oxidative stress in T2DM patients with stage II-III periodontitis.Clinical Relevance:Zinc supplements can be an effective adjunct to nonsurgical periodontal therapy in type 2 diabetic patients with stages II or III periodontitis.

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Total antioxidant/oxidant status in chronic periodontitis patients with type II diabetes following nonsurgical periodontal therapy

Cited by 3 publications

References 23 publications

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

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