Total Antioxidant Capacity, Nutritional Composition and Inhibitory Activity of Unripe Plantain (Musa paradisiacae) on Oxidative Stress in Alloxan Induced Diabetic Rabbits

Eleazu, Chinedum; Okafor, P.N.; Ahamefuna, Ikpeama

doi:10.3923/pjn.2010.1052.1057

Cited by 49 publications

(30 citation statements)

References 7 publications

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“…TAC was significantly increased in BV high-dosetreated group in comparison to the diabetic group which was in contrast to its significant decrease in the diabetic group compared to the normal group. These findings were also in agreement with many studies in which total plasma antioxidant capacity was reduced in uncontrolled diabetes (Eleazu, Okafor, & Ahamefuna, 2010;Polidori et al, 2000). Also, the depletion of TAC in diabetic rats could be due to the reduction in glutathione level (Oseni et al, 2015).…”

Section: Discussionsupporting

confidence: 92%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

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Background: Diabetes mellitus (DM) is one of the most common endocrinal diseases characterized by hyperglycemia and altered metabolism of lipids, carbohydrates, and proteins with an increased risk of many complications. Bioactive drugs extracted from natural sources had been used in a wide range of treatment for many diseases. This work aimed to investigate the potential antidiabetic effect of Egyptian honey bee venom (BV) in alloxan-induced diabetic rats. Subjects and methods: Forty adult male albino rats (140-180 g) were used in the study and divided into five groups each of eight rats. The normal control group, diabetic group, high-and low-dose BV-treated groups, and vildagliptintreated group. Blood samples and pancreases were collected after 6 weeks of the experiment. Results: Treatment of diabetic rats with BV revealed a significant decrease in serum glucose level accompanied by a significant increase in insulin level. Malondialdehyde (MDA), cholesterol, triglycerides, creatinine, and aminotransferases (ALT and AST) levels were significantly decreased after BV treatment in comparison with diabetic animals. Total antioxidant capacity (TAC), glutathione (GSH) contents, and catalase (CAT) activity had improved. Histological examination of the pancreas indicated a marked improvement in the islet architecture and marked regeneration of insulin-secreting β-cell in diabetic BV-treated rats. Conclusion: The study concluded that BV could have the ability to lower glucose level in diabetic rats and enhance insulin secretion, and relieved the various biochemical and histological abnormalities resulted due to diabetes metabolic disorders.

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Section: Discussionsupporting

confidence: 92%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

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“…The decrease in the CHOL value in the rats shows that the diet had positive impact on the lipid metabolism of the diabetic rats [25]. The result agreed with the report of other researchers who reported that plantain and African yam bean have the potentials of combating dyslipidemia which is one of the complications of diabetes [26].…”

Section: Effect Of the Breakfast Products On Blood Glucose Of The Ratssupporting

confidence: 89%

Evaluation of the Hypoglycemic Potentials and Glycemic Index of Ready-to-eat Breakfast Products Using Animal Bioassay

Onuh¹,

Mbaeyi-Nwaoha²,

Ani³

2019

AJFST

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There is need for dietary diversification which involves the use of commonly available cereals, legumes and other nutritious crops to meet nutritional needs of diabetic patients. Dietary diversification could be used to ameliorate micronutrient deficiencies by modifying the diet to include a greater diversity of nutrient-rich foods. The major aim of this study was to produce and evaluate ready-to-eat breakfast product for diabetics from African yam bean (Sphenostylis sternocarpa), sorghum (Sorghum bicolor L.) and unripe plantain (Musa paradisiaca L.

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“…It was observed in this study that alloxan induced diabetic rats had a marked loss in body weight. This would be expected as one of the effects of diabetes is body weight loss, an observation which was also made by Eleazu et al, (2010) [12] that reported weight loss in diabetic rat before the administration of unripe plantain. Alloxan is known to destroy the cells of the pancrease that function in the regulation of insulin secretion and thus leads to an increase in the concentration of blood glucose.…”

Section: Results and Disscussionsupporting

confidence: 57%

EFFECT OF NUTMEG (Myristica fragrans) ON OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC IN WISTAR ALBINO RATS

Oyindamola¹

2017

WJPPS

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ABTRACTSPlants contain many important and potential therapeutic agents for treating several diseases of man. In this study, we investigate and compare the hypoglycemic with lipid profile evaluations of nutmeg (Myristica fragrans) seed on Alloxan-induced diabetic albino rats with the aim of alleviating oxidative stress. Twenty matured male wistar albino rats were acclimatized for one week. The animals were grouped into 5 groups (1, 2, 3, 4 and 4) containing four rats each. Group 1(normal) was fed with rat pellets, Group 2 (negative control) was fed with normal rat feed, Group 3 animals was treated with 0.5ml of 30% aqueous extract of nutmeg (myristical fragrans), while group 4 and 5 animals were treated with 5% and 10% formulated feed respectively. Blood samples were collected for glucose, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and tryglyceride determination.The result of this work revealed that 30% aqueous extract, 5% and 10% supplemented nutmeg (Myristical fragrance) caused increased weight and high density lipoprotein (HDL) concentration and decrease in blood glucose, low density lipoprotein (LDL), triglyceride and total cholesterol. Thus, from this study we conclude that nutmeg (Myristical fragrance) diet exhibited significant anti-hyperglycemic in alloxan-induced diabetic rats.

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Total Antioxidant Capacity, Nutritional Composition and Inhibitory Activity of Unripe Plantain (Musa paradisiacae) on Oxidative Stress in Alloxan Induced Diabetic Rabbits

Cited by 49 publications

References 7 publications

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Evaluation of the Hypoglycemic Potentials and Glycemic Index of Ready-to-eat Breakfast Products Using Animal Bioassay

EFFECT OF NUTMEG (Myristica fragrans) ON OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC IN WISTAR ALBINO RATS

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