Total and Split Renal Function Assessed by Ultrasound Doppler Techniques

Yura, Takafumi; Takamitsu, Yoshihiro; Yuasa, Shigekazu; Miki, Shigehiro; Takahashi, Norihiro; Bandai, Hisashi; Sumikura, Torn; Uchida, Koichi; Tamai, Toyosato; Matsuo, Hirohíde

doi:10.1159/000186375

Cited by 25 publications

(15 citation statements)

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“…Taken together with previous findings showing that the RI and PI reflect the vascular resistance peripheral to the measuring site [7,[13][14][15], the effects of dopamine on the RI and PI in the present study can thus be attributed to a lowered vascular resistance. Although the RI and PI appear to be equally meaningful indices, changes in the RVR correlated strongly with those in the PI, which may be more suitable for the evaluation of renovascular resis tance.…”

Section: Discussionsupporting

confidence: 89%

Role for Doppler Ultrasound in the Assessment of Renal Circulation: Effects of Dopamine and Dobutamine on Renal Hemodynamics in Humans

Yura

Yuasa

Fukunaga

et al. 1995

Nephron

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To examine the utility of Doppler ultrasound in assessing renal hemodynamics, we investigated the effects of dopamine and dobutamine on renal blood flow using Doppler ultrasound technique and conventional clearance tests in 7 healthy volunteers. After visualization of arterial blood flow in the right renal hilus by two-dimensional color flow mapping, the phasic blood flow velocity in the vessel was obtained by a pulsed Doppler method. Intravenous infusion of dopamine at a low dose increased the velocity and decreased the waveform pulsatility of renal artery blood flow without causing any significant changes in blood pressure, heart rate, or cardiac index. In contrast, dobutamine infusion increased the peak systolic velocity in a dose-dependent manner, but did not increase the mean velocity or decrease the waveform pulsatility. Percent changes of renal blood flow during infusions of both agents correlated well with those of the mean velocity. Furthermore, the degrees of changes of the waveform pulsatility were consistent with those of renal vascular resistance obtained from clearance tests and blood pressure. Our results suggest that mean velocity reflects renal blood flow and the pulsatility of blood flow waveform represents renal vascular resistance. We conclude that the effects of vasoactive agents on renal blood flow and renal vascular resistance can be estimated noninvasively, directly, and repeatedly using Doppler ultrasound.

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Section: Discussionsupporting

confidence: 89%

Role for Doppler Ultrasound in the Assessment of Renal Circulation: Effects of Dopamine and Dobutamine on Renal Hemodynamics in Humans

Yura

Yuasa

Fukunaga

et al. 1995

Nephron

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“…The diagnostic validity of Doppler US in renal parenchymal disease is still under debate; however, recent studies have shown that the resistive index (RI) correlates with tubulointerstitial and vascular lesions [2]. Doppler US may also be used to evaluate orbital vascular flow velocities and characteristics [3].…”

Section: Introductionmentioning

confidence: 99%

Correlation between the Resistive Index Values of Renal and Orbital Arteries

Baştürk

Akcay

Albayrak

et al. 2012

Kidney Blood Press Res

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Background: Resistive index (RI) is an indirect measurement of blood flow resistance that can be used to evaluate vascular damage. Aims: The purpose of this study is to evaluate the association between RI values of orbital and intrarenal arteries by means of Doppler ultrasonography (US). Methods: We evaluated 103 diabetic patients. As a control group, 30 subjects were examined. The patients were divided into two groups. Group 1 consisted of patients with urinary albumin excretion (UAE) <300 mg/day and estimated glomerular filtration rate (eGFR) levels >90 ml/min (n = 50); Group 2 had a UAE >300 mg/day and/or eGFR levels between 89 and 60 ml/min (n = 53). The association between RI values obtained with Doppler US of the ophthalmic artery, central retinal artery, posterior ciliary artery and intrarenal arteries were calculated. Results: Both orbital and intrarenal arterial RI values in Group 1 and Group 2 were higher than the control group (p = 0.001); furthermore, values were higher in Group 2 than in Group 1 (p = 0.0004/0.029/0.036, p = 0.016, respectively). A positive correlation was found between orbital and intrarenal arterial RI values in Group 2 (r = 0.475, 0.285, 0.363, p < 0.01, respectively). Conclusion: Both orbital and renal arterial RI values were shown to be higher than the control group. Further, a trend towards higher RI values was observed with renal disease. RI may be useful as one of the markers for early diagnosis and follow-up of diabetic nephropathy and retinopathy.

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“…These measurements, easily obtained in the transplanted kidney for its eterotopic position in the iliac fossa, can also be performed in the native kidneys [30] in the study of intraand extraparenchymal renal vascular problems and of any type of a spontaneous form of renal disease. …”

Section: Discussionmentioning

confidence: 99%

“…A third factor of caution in the interpretation of Doppler results is the increase in RI and PI along with the elevation in creatinine plasma levels or with the reduction in the nephrotic mass [26,29,30], The physiological significance of this fact is obscure, but must be taken into account when the data obtained from patients with reduced renal function are to be interpreted. For a correct interpretation of Doppler records, it is therefore necessary to know creatinine plasma levels.…”

Section: Recording Doppler Sonogramsmentioning

confidence: 99%

Effect of Cyclosporin A on Renal Cortical Resistances Measured by Color Doppler Flowmetry on Renal Grafts

Palo

Rivolta²,

Elli³

et al. 1993

Nephron

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Doppler spectra were recorded at different cyclosporin A (CSA) levels (trough and peak) in 30 stable renal-transplanted outpatients: 15 with unimpaired renal function (plasma creatinine < 150 μmol/l) and 15 with renal impairment (plasma creatinine 150-350 μmol/l). Pulsatility (PI) and resistive indexes (RI) have been measured in the renal artery at the hilum and in the renal cortex. RI and PI were markedly increased (p < 0.0001) in the cortex at peak time while in the renal artery no significant changes were observed. These variations were statistically related with CSA blood levels (PI = p < 0.02; r = 0.54, RI = p < 0.05; r = 0.45). These effects were also found in the presence of renal damage. CSA dose-dependently reduces cortical blood flow, causing a persistent arteriolar vasoconstriction and a reduction in diastolic flow. This effect can be measured in man in a noninvasive and repeatable way using color Doppler sonograms.

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Total and Split Renal Function Assessed by Ultrasound Doppler Techniques

Cited by 25 publications

References 0 publications

Role for Doppler Ultrasound in the Assessment of Renal Circulation: Effects of Dopamine and Dobutamine on Renal Hemodynamics in Humans

Role for Doppler Ultrasound in the Assessment of Renal Circulation: Effects of Dopamine and Dobutamine on Renal Hemodynamics in Humans

Correlation between the Resistive Index Values of Renal and Orbital Arteries

Effect of Cyclosporin A on Renal Cortical Resistances Measured by Color Doppler Flowmetry on Renal Grafts

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