Total and Specific Immunoglobulin E and Their Relationship to Respiratory Symptoms in Quebec Children and Adolescents

Abstract

Allergic sensitization is a major determinant in the development of asthma, wheezing and rhinitis in children and adolescents in the province of Québec.

The significance of serum total immunoglobulin E for in vitro diagnosis of allergic rhinitis

“…Factors that can affect IgE levels, including the environment, location, age, and sex, did not affect our results. The number and type of allergens in symptomatic patients were not found to affect tIgE levels in this study as opposed to other reports …”

Associations Between Asthma and Sensitization to Pet or Pollen Allergens in Young Swedish Twins – The STOPPA Study

“…Our cohort analyses highlighted significant associations between sensitization to pet and pollen allergens and asthma morbidity, which is in line with several previous studies (Lévesque et al, 2005; Simpson et al, 2005; Simpson et al, 2015). The novelty of our study is that many of these associations remain within twin pairs, although with wider confidence intervals for both MZ and DZ pairs.…”

“…Simpson et al (2015), who in their study on 11-year-old children tested allergen components grouped into categories, found the category including all domestic pet allergens to be most strongly associated with asthma morbidity. Lévesque et al (2005) found significant differences in sensitization to cat in children with and without asthma, whereas none were observed for dog and timothy sensitization. In accordance with Ghunaim et al (2006), we noted higher estimates for the associations for birch pollen and asthma than for timothy.…”

“…However, not all sensitized individuals develop asthma and, conversely, asthma patients are not always sensitized (Illi et al, 2001). Clinical and epidemiological studies have demonstrated considerable variability in the associations between asthma and total serum IgE (Stromgaard et al, 2011), between asthma and a variety of specific IgEs (sIgEs; Almqvist et al, 2007; Arroyaye et al, 2013; Ghunaim et al, 2006; Gruchalla et al, 2005; Hoffmann-Petersen et al, 2013; Lévesque et al, 2005; Rotsides et al, 2010; Simpson et al, 2005), and between asthma and total or sIgEs in geographically disparate cohorts (Weinmayr et al, 2007).…”

Cat sensitization identified by recombinant Fel d 1 several years before symptoms - results from the bamse cohort

“…Sensitization to indoor allergens is an important risk factor for allergic asthma (1–6). Besides house dust mite and cockroach, domestic cat is one of the most significant sources of indoor allergens world‐wide.…”