Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development

Ball, William S.; Byars, Anna W.; Schapiro, M. B.; Bommer, Wendy A.; Carr, April; German, Alexander; Dunn, Scott; Rivkin, M. J.; Waber, Deborah P.; Mulkern, Robert V.; Vajapeyam, Sridhar; Chiverton, Abigail; Davis, Peter E.; Koo, Julie; Marmor, Jacki; Mrakotsky, Christine; Robertson, Richard L.; McAnulty, Gloria; Brandt, Michael E.; Fletcher, Jack Μ.; Kramer, Larry A.; Yang, Guoyuan; McCormack, Cara; Hebert, Kathleen M.; Volero, Hilda; Botteron, Kelly N.; McKinstry, Robert C.; Warren, William M.; Nishino, Tomoyuki; Almli, C. Robert; Todd, Richard D.; Constantino, John N.; McCracken, John; Levitt, James J.; Alger, J. R.; O’Neill, Joseph; Toga, A.W.; Asarnow, Robert F.; Fadale, David; Heinichen, Laura; Ireland, Cedric; Wang, D. J.; Moss, E. Daniel; Zimmerman, Robert A.; Bintliff, Brooke; Bradford, Ruth; Jp, Newman; Evans, Alan C.; Arnaoutelis, Rozie; Pike, G. Bruce; Collins, D. Louis; Leonard, Gabriel; Paus, Tomáš; Zijdenbos, Alex P.; Das, Saptarshi; Fonov, Vladimir; Fu, Luke; Harlap, Jonathan; Leppert, Ilana R.; Milovan, D.; Vins, Dario; Zeffiro, Thomas; Meter, J. Van; Lange, Nicholas; Froimowitz, Michael P.; Rainey, Cheryl A.; Henderson, Shalom K; Edwards, Jennifer; Dubois, D.; Smith, Kate; Singer, Tori; Wilber, Aaron A.; Pierpaoli, Carlo; Basser, Peter J.; Chang, Lin‐Ching; Walker, Lindsay; Freund, Lisa S.; Rumsey, Judith M.; Baskir, Lauren; Stanford, Laurence; Sirocco, Karen; Gwinn‐Hardy, Katrina; Spinella, Giovanna

doi:10.1093/cercor/bhr018

Cited by 314 publications

(168 citation statements)

References 61 publications

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“…3,6 The most suitable study for a comparison of our data with that of healthy volunteers was published in 2012. 20 A comparison of brain volumes of our patients for whole-brain GM and WM, whole cerebellum, and ventricles starting at 4.8 years of age revealed distinctively smaller volumes for whole-brain GM, whole-brain WM, and the cerebellum compared with healthy controls. In contrast, the size of the lateral ventricles was increased.…”

Section: Discussionmentioning

confidence: 67%

Volumetric Description of Brain Atrophy in Neuronal Ceroid Lipofuscinosis 2: Supratentorial Gray Matter Shows Uniform Disease Progression

Löbel¹,

Sedlacik²,

Nickel³

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Experimental therapies for ceroid lipofuscinosis, neuronal, 2 (CLN2), a genetic disorder of childhood associated with progressive brain atrophy, are currently being developed. Because quantitative descriptions of the natural course of brain volume loss are needed to evaluate novel therapies, we performed MR imaging volumetry of patients with CLN2 to identify a suitable MR imaging marker of disease progression.

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Section: Discussionmentioning

confidence: 67%

Volumetric Description of Brain Atrophy in Neuronal Ceroid Lipofuscinosis 2: Supratentorial Gray Matter Shows Uniform Disease Progression

Löbel¹,

Sedlacik²,

Nickel³

et al. 2016

AJNR Am J Neuroradiol

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“…Hemispheric asymmetries in both frontal and temporal lobes have also been reported in several studies [1,7,11]. The Brain Development Cooperative Group [1] reported that nearly every regional volume shows a leftward hemispheric asymmetry, particularly WM in the temporal lobes.…”

Section: Introductionmentioning

confidence: 65%

“…MRI provides a non-invasive method to observe brain changes in living people during development. MRI thus enables researchers to study pediatric brain development, which could support theories and help answer questions related to child development [1]. …”

Section: Introductionmentioning

confidence: 99%

Developmental Trajectories of the Fronto-Temporal Lobes from Infancy to Early Adulthood in Healthy Individuals

Tanaka

Matsui²,

Uematsu³

et al. 2012

Dev Neurosci

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Brain development during early life in healthy individuals is rapid and dynamic, indicating that this period plays a very important role in neural and functional development. The frontal and temporal lobes are known to play a particularly important role in cognition. The study of healthy frontal and temporal lobe development in children is therefore of considerable importance. A better understanding of how these brain regions develop could also aid in the diagnosis and treatment of neurodevelopmental disorders. Some devel-opmental studies have used magnetic resonance imaging (MRI) to examine infant brains, but it remains the case that relatively little is known about cortical brain development in the first few years of life. In the present study we examined whole brain, temporal lobe and frontal lobe developmental trajectories from infancy to early adulthood in healthy individuals, considering gender and brain hemisphere differences. We performed a cross-sectional, longitudinal morphometric MRI study of 114 healthy individuals (54 females and 60 males) aged 1 month to 25 years old (mean age ± SD 8.8 ± 6.9). We measured whole brain, temporal and frontal lobe gray matter (GM)/white matter (WM) volumes, following previously used protocols. There were significant non-linear age-related volume changes in all regions. Peak ages of whole brain, temporal lobe and frontal lobe development occurred around pre-adolescence (9-12 years old). GM volumes for all regions increased significantly as a function of age. Peak age was nevertheless lobe specific, with a pattern of earlier peak ages for females in both temporal and frontal lobes. Growth change in whole brain GM volume was larger in males than in females. However, GM volume growth changes for the temporal and frontal lobes showed a somewhat different pattern. GM volume for both temporal and frontal lobes showed a greater increase in females until around 5-6 years old, at which point this tendency reversed (GM volume changes in males became greater), with male GM volume increasing for a longer time than that of females. WM volume growth changes were similar across regions, all increasing rapidly until early childhood but slowing down thereafter. All regions displayed significant rightward volumetric asymmetry regardless of sex. Furthermore, the right temporal and frontal lobes showed a greater volumetric increase than the left for the first several years, with this tendency reversing at around 6 years of age. In addition, the left frontal and temporal lobes increased in volume for a longer period of time. Taken together, these findings indicated that brain developmental trajectories differ depending on brain region, sex and brain hemisphere. Gender-related factors such as sex hormones and functional laterality may affect brain development.

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“…For example, the most hypoallometric of cerebellar lobules in our study-Crus II-is notable for having undergone the greatest relative expansion in the human lineage (Balsters et al, 2010). Collectively, these observations suggest that the long-debated degree of alignment between interspecific and intraspecific patterns of brain scaling (Finlay and Darlington, 1995;Barton and Harvey, 2000) not only varies across different taxonomic granularities (Willemet, 2012), but also across different anatomical granularities.…”

Section: Normative Allometry Of the Human Cerebellummentioning

confidence: 93%

“…Total brain volume measurements were acquired by submitting scans to the CIVET 1.1.10 pipeline for automated morphometric analysis (Ad the combined estimates of total gray and white matter volume as calculated by CIVET using a validated neural net approach to voxel classification (Zijdenbos et al, 2002;Cocosco et al, 2003). To align our methodology with prior (predominantly phylogenetic) studies of cerebellar allometry (e.g., Barton and Harvey, 2000), we entered total brain volume in all analyses after first subtracting total cerebellar volume (estimated as detailed below). For notational clarity, we will refer to this adjusted index of total brain volume as aTBV.…”

Section: Image Acquisition and Processingmentioning

confidence: 99%

Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization

et al. 2017

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The cerebellum is a large hindbrain structure that is increasingly recognized for its contribution to diverse domains of cognitive and affective processing in human health and disease. Although several of these domains are sex biased, our fundamental understanding of cerebellar sex differences-including their spatial distribution, potential biological determinants, and independence from brain volume variation-lags far behind that for the cerebrum. Here, we harness automated neuroimaging methods for cerebellar morphometrics in 417 individuals to (1) localize normative male-female differences in raw cerebellar volume, (2) compare these to sex chromosome effects estimated across five rare sex (X/Y) chromosome aneuploidy (SCA) syndromes, and (3) clarify brain size-independent effects of sex and SCA on cerebellar anatomy using a generalizable allometric approach that considers scaling relationships between regional cerebellar volume and brain volume in health. The integration of these approaches shows that (1) sex and SCA effects on raw cerebellar volume are large and distributed, but regionally heterogeneous, (2) human cerebellar volume scales with brain volume in a highly nonlinear and regionally heterogeneous fashion that departs from documented patterns of cerebellar scaling in phylogeny, and (3) cerebellar organization is modified in a brain size-independent manner by sex (relative expansion of total cerebellum, flocculus, and Crus II-lobule VIIIB volumes in males) and SCA (contraction of total cerebellar, lobule IV, and Crus I volumes with additional X-or Y-chromosomes; X-specific contraction of Crus II-lobule VIIIB). Our methods and results clarify the shifts in human cerebellar organization that accompany interwoven variations in sex, sex chromosome complement, and brain size.

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Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development

Cited by 314 publications

References 61 publications

Volumetric Description of Brain Atrophy in Neuronal Ceroid Lipofuscinosis 2: Supratentorial Gray Matter Shows Uniform Disease Progression

Volumetric Description of Brain Atrophy in Neuronal Ceroid Lipofuscinosis 2: Supratentorial Gray Matter Shows Uniform Disease Progression

Developmental Trajectories of the Fronto-Temporal Lobes from Infancy to Early Adulthood in Healthy Individuals

Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization

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