Total and free thyroid hormone concentrations after elective surgery.

Prescott, R. W. G.; Yeo, P. P. B.; Watson, M. J.; Johnston, I. D. A.; Ratcliffe, J G; Evered, David

doi:10.1136/jcp.32.4.321

Cited by 25 publications

(17 citation statements)

References 23 publications

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“…11 The early decrease in serum T 4 concentration in the present study is not likely to be due to altered protein binding, as the fT 4 fraction did not change. Increased metabolism of T 4 , 21 increased transport of T 4 into cells, and decreased thyroid hormone secretion 6 have been proposed as possible mechanisms for the decrease in serum T 4 concentration reported in human surgical patients in the absence of altered binding to carrier proteins.…”

Section: Discussionmentioning

confidence: 99%

Influence of Isoflurane General Anesthesia or Anesthesia and Surgery on Thyroid Function Tests in Dogs

Wood

Panciera

Berry

et al. 2008

Journal of Veterinary Internal Medicine

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Background: Anesthesia and surgery affect thyroid function tests in humans but have not been studied in dogs. Hypothesis: Anesthesia and anesthesia with surgery will affect thyroid function tests in dogs. Animals: Fifteen euthyroid dogs. Methods: Prospective, controlled, interventional study. Dogs were assigned to one of 3 groups: control, general anesthesia, and general anesthesia plus abdominal exploratory surgery. Dogs in the anesthesia and surgery groups were premedicated with acepromazine and morphine, induced with propofol, and maintained on isoflurane. Samples for measurement of serum thyroxine (T 4 ), free T 4 (fT 4 ) by equilibrium dialysis, triiodothyronine (T 3 ), reverse T 3 (rT 3 ), and thyroid-stimulating hormone concentrations were collected from each dog immediately before premedication, at multiple times during anesthesia, surgery, 4, 8, 12, 24, 36, and 48 hours after anesthesia, once daily for an additional 5 days, and once 14 days after anesthesia. Sampling was performed at identical times in the control group.Results: Serum T 4 decreased significantly from baseline in the surgery and anesthesia groups compared with the control group at 0.33 (P 5 0.043) and 1 hour (P 5 0.018), and 2 (P 5 0.031) and 4 hours (P 5 0.037), respectively, then increased significantly in the surgery group compared with the control group at 24 hours (P 5 0.005). Serum T 3 decreased significantly from baseline in the anesthesia group compared with the control group at 1 hour (P 5 0.034). Serum rT 3 increased significantly from baseline in the surgery group compared with the control and anesthesia groups at 8 (P 5 0.026) and 24 hours (P 5 0.0001) and anesthesia group at 8, 12, 24, and 36 hours (P 5 0.004, P 5 0.016, P 5 0.004, and P 5 0.014, respectively). Serum fT 4 increased significantly from baseline in the surgery group compared to the control at 24 hours (P 5 0.006) and at day 7 (P 5 0.037) and anesthesia group at 48 hours (P 5 0.023).Conclusions and Clinical Importance: Surgery and anesthesia have a significant effect on thyroid function tests in dogs.

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Section: Discussionmentioning

confidence: 99%

Influence of Isoflurane General Anesthesia or Anesthesia and Surgery on Thyroid Function Tests in Dogs

Wood

Panciera

Berry

et al. 2008

Journal of Veterinary Internal Medicine

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“…It is generally agreed that abdominal surgery causes a decrease in circulating T3 concentrations and a simultaneous reciprocal increase in rT3 values for several days after surgery (Burr et al, 1975;Hagenfeldt et al, 1979;Prescott et al, 1979;Wolfson et al, 1981). While the decrease in T3 concentrations is consistently noted, the increase in rT3 concentrations is not always found during or soon after surgery (Adami et al, 1978;Chan et al, 1978;Blichert-Toft et al, 1979;Hagenfeldt et al, 1979;Rutberg et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Anaesthesia, Not Surgical Stress, Induces Increases in Serum Concentrations of Reverse Triiodothyronine and Thyroxine during Surgery

Chikenji¹,

Mizutani²,

Kitsukawa³

2009

Exp Clin Endocrinol Diabetes

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Effects of anaesthesia on serum concentrations of thyroid hormones during and soon after abdominal surgery were examined in 29 patients undergoing cholecystectomy (n = 22) or removal of gastric cancer (n = 7). They were given one of the following anaesthetics in combination with nitrous oxide in oxygen: epidural bupivacaine, enflurane, pentazocine, ketamine, halothane, epidural bupivacaine and enflurane. Regardless of type of anaesthesia, T3 decreased significantly during and after surgery. T4 and rT3 increased markedly when either enflurane or halothane was given but not with the other anaesthetic agents; they then decreased toward pre-surgical levels after surgery. There was no correlation between changes in rT3 and those in cortisol or free fatty acids. TSH fluctuated little. These results show that the increases in rT3 and T4 during and soon after surgery are due not to surgical trauma but to inhalational anaesthetics such as enflurane and halothane.

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“…Sowohl nach abdominal-als auch nach thoraxclairurgischen Eingriffen kommt es zur Ausbildung eines ,,Low-T3 Syndrome" nfit der gr6Bten Auspfiigung am ersten postoperativen Tag [44,58,62,82]. Es konnte gezeigt werden, daB Patienten, die nach thoraxchirurgischen Eingriffen Komplikationen hatten, signifikant niedrige T3-Konzentrationen in der postoperativen Phase aufwiesen [62] [57].…”

Section: S Childdr• Orm O Nparame-ter Bei Verschiedenen Nicht-thyunclassified

“…Meist wurden erniedrigte Schilddrª trationen bei verschiedenen Erkrankungen, zum Beispiel bei Sepsis, nach Operationen, Myokardinfarkt, nach l~ingerem Fasten u. a., .gefunden [8,44,48,58,81,82]. Diese Anderungen sind nicht Ausdruck einer Hypothyreose, sondem das Ergebnis eines neuen Gleichgewichts in der Wechselwirkung zwischen Schilddrª Hypophyse und Hypothalamus.…”

unclassified

„Non-Thyroidal Illness” oder Syndrom veränderter Schilddrüsenhormonparameter bei Patienten mit nichtthyreoidalen Erkrankungen

Reinhardt

Mann

1998

Med Klin

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NTI is associated with various alterations in thyroid hormone parameters when no intrinsic thyroid hormone disease exists. The severity of NTI reflects clinical outcome and clinical amelioration is associated with normalization of thyroid hormone parameters. There is no need for specific therapeutic intervention such as the administration of thyroid hormones in patients with the various forms of the NTI-syndrome.

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Total and free thyroid hormone concentrations after elective surgery.

Cited by 25 publications

References 23 publications

Influence of Isoflurane General Anesthesia or Anesthesia and Surgery on Thyroid Function Tests in Dogs

Influence of Isoflurane General Anesthesia or Anesthesia and Surgery on Thyroid Function Tests in Dogs

Anaesthesia, Not Surgical Stress, Induces Increases in Serum Concentrations of Reverse Triiodothyronine and Thyroxine during Surgery

„Non-Thyroidal Illness” oder Syndrom veränderter Schilddrüsenhormonparameter bei Patienten mit nichtthyreoidalen Erkrankungen

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