Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

Andersen, Shaneda Warren; Shu, Xiao‐Ou; Cai, Qiuyin; Khankari, Nikhil K.; Steinwandel, Mark; Jurutka, Peter W.; Blot, William J.; Wang, Zheng

doi:10.1158/1055-9965.epi-17-0133

Cited by 23 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Altogether, these processes result in decreased total serum protein which was also seen in our study (Table I). However, our results did not demonstrate significant independ-ent contribution of VDBP to the modulation of risk for CRC development (Table V), which is in line with previous researches (28,29), thus suggesting that the impact of VDBP during CRC progression is more likely indirect and related to vitamin D.…”

Section: Discussionsupporting

confidence: 90%

“…It should also be mentioned that we observed significantly lower VDBP levels in CRC patients when compared to healthy participants ( Table I). Such results were expectable since VDBP is primarily synthesized by the liver and it is well documented that tumor-associated inflammation and production of cytokines can decrease hepatic protein synthesis, while on the other hand, malignant cells can increasingly uptake serum proteins (28). Altogether, these processes result in decreased total serum protein which was also seen in our study (Table I).…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer

Vladimirov

Zeljković

Gojković

et al. 2019

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Summary Background Vitamin D deficiency is repeatedly reported in colorectal cancer (CRC). Since cholesterol and vitamin D share common precursor 7-dehydrocholesterol (7-DHC), it would be important to explore the associations of key vitamin D metabolites and serum lipid parameters in patients with high and low grade CRC. The aim of this study was to analyze relationships between serum 25(OH)D3, 24,25(OH)2D3 and 7-DHC levels and serum lipids in patients with CRC, and to evaluate their potential for prediction of risk for development of high grade CRC. Methods We recruited 82 patients CRC and 77 controls. 7-DHC, 25(OH)D3 and 24,25(OH)2D3 were quantified by LC-MS/MS methods. Results 7-DHC, 25(OH)D3 and vitamin D metabolic ratio (VDMR) were significantly lower in CRC patients than in control group (P<0.001, P<0.010, P<0.050 and P<0.050, respectively). 25(OH)D3 levels were higher in patients with grade I CRC when compared to grade II (P<0.050). All vitamin D metabolites positively correlated with total cholesterol (TC) concentration in CRC patients. 25(OH)D3 was significant predictor of increased CRC risk (P<0.010). After adjustment for TC concentration, 25(OH)D3 lost its predictive abilities. However, 25(OH)D3 remained significant predictor of poorly differentiated type of cancer (P<0.050). Conclusions We found significant positive association between vitamin D status and serum total cholesterol. Although low 25(OH)D3 was found to be a significant risk factor for CRC development, the obtained results primarily suggest profound impact of cholesterol level on vitamin D status in CRC. However, our results suggest that low 25(OH)D3 might independently contribute to development of poorly differentiated tumor.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer

Vladimirov

Zeljković

Gojković

et al. 2019

Journal of Medical Biochemistry

View full text Add to dashboard Cite

show abstract

“…Results from univariate analysis showed that the serum concentration of pre‐ and post‐operative 25(OH)D in male patients and rectal tumors were significantly higher ( P = .003, P = .007, P = .007, and P = .032, respectively). Andersen et al found that the inverse association between serum 25(OH)D and CRC was more prominent in females than males . A meta‐analysis including 1248 cases of CRC suggested that 25(OH)D had stronger inverse associations with colon than with rectal tumors .…”

Section: Discussionmentioning

confidence: 99%

“…Benefited by the development of screening tools for early detection, more and more patients could be treated at an early stage; however, the incidence and mortality of CRC among adults aged under 50 years is increasing in the United States . Accumulating evidence indicates that high levels of circulating vitamin D is an anti‐cancer factor, which may reduce the risk of CRC …”

Section: Introductionmentioning

confidence: 99%

The association of serum vitamin D–binding protein and 25‐hydroxyvitamin D in pre‐operative and post‐operative colorectal cancer

Liang

Jiang

Chi

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Background: The association between vitamin D-binding protein (VDBP) and 25-hydroxyvitamin D (25 (OH)D) with colorectal cancer (CRC) is still ambiguous. This study was to further investigate the relationship between serum VDBP, 25 (OH)D levels and the clinical and pathological features of patients with CRC.Methods: Enzyme-linked immunosorbent assay (ELISA) and chemiluminescence immunoassay were used to analyze the VDBP and 25(OH)D concentrations in serum.Pearson's correlation analysis was applied to evaluate the association between serum VDBP and 25(OH)D levels in CRC. Conditional logistic regression was performed to analyze the prediction value of serum VDBP or 25(OH)D as a risk factor for CRC. Results:The serological levels of 25(OH)D in patients were significantly lower than in healthy individuals, while VDBP levels were significantly higher than in healthy controls. The serum VDBP in pre-operative was significantly lower than in post-operative samples, while the serum 25(OH)D from pre-operative patients was significantly higher than post-operative patients. Patients with tumors with higher stage and increased lymph node involvement had lower serum post-operative VDBP levels. In addition, our results showed that the pre-operative VDBP level is a risk factor of CRC. Conclusions:The levels of serum 25(OH)D and VDBP were both associated with CRC.Thus, serum 25(OH)D and VDBP levels might be of value in evaluating the pathogenesis and risk of CRC in the future. Moreover, serum VDBP or 25(OH)D levels were associated with patient's clinical and pathological features providing data for risk and prognostic prediction.Colorectal cancer (CRC) is a common type of cancer worldwide. 1 In China, the estimated new cases and deaths of CRC were 376 300 and 191 000, respectively, in 2015. 2 Benefited by the development of screening tools for early detection, more and more patients could be treated at an early stage; however, the incidence and mortality of CRC among adults aged under 50 years is increasing in the United States. 3Accumulating evidence indicates that high levels of circulating vitamin D is an anti-cancer factor, which may reduce the risk of CRC. [4][5][6] Vitamin D (VD) is photochemically synthesized in the skin when exposed to ultraviolet B (UVB) radiation or ingested from food and/ or supplements. Once getting into blood circulation, VD is hydroxylated and forms 25-hydroxyvitamin D [25(OH)D] in the liver, the well-known biomarker of VD status. Then, 25(OH)D is hydroxylated and forms 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney and other organs, the bioactive form of VD. 7 Recent studies found that free 25(OH)D may be an independent CRC prognostic biomarker. 8 Vitamin D-binding protein (VDBP), primarily vitamin D carrier ...

show abstract

“…Es gilt aber als wahrscheinlich, dass ein guter Vitamin-D-Spiegel eine protektive Wirkung hat. Dieses gilt insbesondere für Prostata-Ca, Mamma-Ca, kolorektale Tumoren, Lungentumoren und hämtologische Malignome[40][41][42][43][44][45][46][47][48][49][50][51][52].…”

unclassified

Mikronährstoffe in der Onkologie: Risiko und Nutzen

Mücke

Micke

Büntzel

et al. 2020

Deutsche Zeitschrift für Onkologie

View full text Add to dashboard Cite

Zusammenfassung Hintergrund Das Interesse sowohl von betreuenden Ärzten als auch Tumorpatienten an der zusätzlichen Einnahme von Mikronährstoffen während einer onkologischen Therapie mit unterschiedlichen Intentionen nimmt zu. Dieses Update liefert deshalb eine Standortbestimmung zum zusätzlichen Einsatz von ausgewählten Mikronährstoffen während der Tumortherapie. Methoden Es wurde eine Literaturrecherche hinsichtlich des Einsatzes von ausgewählten Mikronährstoffen in der Onkologie, die bis 2018 in zitierfähigen Journalen erschienen sind, durchgeführt. Ergebnisse Daten zu Mikronährstoffen, die sowohl hinsichtlich der Lebensqualität als auch der Prognose einen Nutzen für onkologische Patienten bringen, als auch Erkenntnisse zu Mikronährstoffen, die für die Patienten keinen Benefit haben oder sogar schaden, werden präsentiert. Die gute Datenlage hinsichtlich Vitamin D und Selen erlaubt hier die Empfehlung zur Supplementation nach Spiegelbestimmung im Serum. Schlussfolgerung Nicht nur vorrangig onkologisch tätige Ärzte, sondern auch alle Ärzte, die Tumorpatienten mitbetreuen, sollten Kenntnisse über die wichtigsten Mikronährstoffe haben, um diese an die Patienten weiterzugeben und sie auch gezielt zum Nutzen der Patienten einzusetzen.

show abstract

Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

Cited by 23 publications

References 32 publications

Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer

Associations of cholesterol and vitamin D metabolites with the risk for development of high grade colorectal cancer

The association of serum vitamin D–binding protein and 25‐hydroxyvitamin D in pre‐operative and post‐operative colorectal cancer

Mikronährstoffe in der Onkologie: Risiko und Nutzen

Contact Info

Product

Resources

About