Total and Differential White Blood Cell Counts in Late Life Predict 8‐Year Incident Stroke: The Honolulu Heart Program

Huh, Ji Young; Ross, G. Webster; Chen, Randi; Abbott, Robert D.; Bell, Christina; Willcox, Bradley J.; Launer, Lenore J.; Petrovitch, Helen; Kaya, Brock

doi:10.1111/jgs.13298

Cited by 20 publications

(18 citation statements)

References 27 publications

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“…A recent UK large cohort study did not find any association of eosinophils or lymphocytes with stroke or CHD 40 . Our results for stroke are concordant with the literature 41 , 42 as neutrophils were the only component of the WBC count associated with stroke but we did not detect a significant association between neutrophils and CHD. When adjusting for known CVD risk factors, the association between the neutrophil and risk of stroke disappeared, indicating that the effect of neutrophils is not independent from those CVD risk factors.…”

Section: Discussionsupporting

confidence: 91%

Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study

Lassale

Curtis

Abete

et al. 2018

Sci Rep

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All blood cells (white blood cells [WBC], red blood cells [RBC] and platelets) can play a role in atherosclerosis. Complete blood count (CBC) is widely available in clinical practice but utility as potential risk factors for cardiovascular disease (CVD) is uncertain. Our aim was to assess the associations of pre-diagnostic CBC with incidence of CVD in 14,362 adults free of CVD and aged 47.8 (±11.7) years at baseline, followed-up for 11.4 years (992 incident cases). Cox proportional hazards regressions were used to estimate HRs and 95%CI. Comparing the top (T3) to bottom (T1) tertile, increased total WBC, lymphocyte, monocyte and neutrophil counts were associated with higher CVD risk: 1.31 (1.10; 1.55), 1.20 (1.02; 1.41), 1.21 (1.03; 1.41) and 1.24 (1.05; 1.47), as well as mean corpuscular volume (MCV: 1.23 [1.04; 1.46]) and red cell distribution width (RDW: 1.22 [1.03; 1.44]). Platelets displayed an association for count values above the clinically normal range: 1.49 (1.00; 2.22). To conclude, total and differential WBC count, MCV, RDW and platelet count likely play a role in the aetiology of CVD but only WBC provide a modest improvement for the prediction of 10-year CVD risk over traditional CVD risk factors in a general population.

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Section: Discussionsupporting

confidence: 91%

Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study

Lassale

Curtis

Abete

et al. 2018

Sci Rep

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“…However, inconclusive associations were found in hemorrhagic stroke. 9 , 10 , 31 , 44 In concordant with this study, the CKB study showed that higher systemic inflammation measured by CRP was positively associated with the risk of hemorrhagic stroke, 44 while other prospective studies did not find the association between WBC and the incident of hemorrhagic stroke. A possible explanation was that the sample size in previous studies was insufficient to examine the relationships with the risk for hemorrhagic stroke owning to its relatively low incidence.…”

Section: Discussionsupporting

confidence: 84%

The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals

Jin¹,

Wu²,

Chen³

et al. 2021

JIR

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Background: SII and SIRI are two novel systemic inflammation indexes that were suggested in predicting poor outcomes in cancers. However, no studies have examined their effect on cardiovascular diseases (CVDs) and all-cause mortality. Thus, this study aims to investigate associations between SII, SIRI, and the risks for CVDs and all-cause mortality. Methods: A total of 85,154 participants from the Kailuan cohort were included and followed up for incidents of CVDs (including MI, stroke) and all-cause death for 10 years. Multiple Cox regression was used to calculate the adjusted hazard ratios (HRs). Results: During the follow-up period, 4262 stroke events, 1233 MI events, and 7225 allcause deaths were identified, respectively. Compared with the lowest quantile (Q1) of SII or SIRI, after adjusted for most cardiovascular risk factors, both indexes showed positive associations with the risk for stroke (adjusted HRs in Q4 were 1.264 (95% CI: 1.157,1.382) for SII, 1.194 (95% CI: 1.087,1.313) for SIRI), and all-cause death (adjusted HRs in Q4 were 1.246 (95% CI: 1.165,1.331) for SII, 1.393 (95% CI: 1.296,1.498) for SIRI). Additionally, higher SII and SIRI are also associated with increased risk of hemorrhagic stroke and ischemic stroke. Higher SIRI but not SII exhibited a higher MI risk, the adjusted HR in Q4 was 1.204 (1.013,1.431). The significant association remained after additional adjustment for CRP. Subgroup analysis and sensitivity analysis displayed consistent results except for SIRI with MI, where the association did not arrive at significance in subjects aged ≥60. Conclusion: Elevated SII and SIRI increased the risk of stroke, two stroke subtypes, and all-cause death. Higher SIRI, but not SII associated with increased MI incidence, and the association of SIRI was only significant in subjects aged <60.

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“…Monocyte count also emerges to be an independent risk factor for atherosclerotic diseases. However, some epidemiologic and prospective cohort studies indicated that monocytosis was not associated with CHD [49], cardiovascular death [50] or stroke [51]. Moreover, increased circulating monocyte count was correlated with good coronary collateral growth in patients with severely stenotic CAD [52] and with diabetes [53].…”

Section: Resultsmentioning

confidence: 99%

Potential of Monocyte Count for the Assessment of Cardiovascular Disease

Matsumura¹,

Yamamoto²,

Tsujita³

et al. 2017

Cardiovasc Pharm Open Access

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Atherosclerosis is a chronic inflammatory disease proceeding from an imbalance in lipid metabolism and immune responses. Since leukocytes, especially monocytes and monocyte-derived macrophages, play pivotal roles in the progression of atherosclerosis, it is possible that monocyte count is a beneficial marker for predicting cardiovascular disease (CVD). Many epidemiologic and clinical studies have indicated monocytosis to be an independent predictor of cardiovascular events, both in healthy individuals at baseline and in patients with CVD or with high risk diseases for CVD, such as diabetes, dyslipidemia, hypertension and chronic kidney disease. This relationship has been observed in prospective and retrospective cohort studies, and endures after adjustment for several CVD risk factors. Other indicators utilized monocyte count, such as lymphocyte-to-monocyte ratio, monocyte-to-lymphocyte ratio and monocyte-to-high-density lipoprotein cholesterol ratio, were also independently associated with cardiovascular events and its mortality. In this review, we discussed the clinical utility of the monocyte count as a predictive marker in atherosclerotic diseases.

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Total and Differential White Blood Cell Counts in Late Life Predict 8‐Year Incident Stroke: The Honolulu Heart Program

Cited by 20 publications

References 27 publications

Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study

Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study

The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals

Potential of Monocyte Count for the Assessment of Cardiovascular Disease

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