Total Adverse Childhood Experiences and Preterm Birth: A Systematic Review

Sulaiman, Salima; Premji, Shahirose; Tavangar, Farideh; Yim, Ilona S.; Lebold, Margaret

doi:10.1007/s10995-021-03176-6

Cited by 18 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neonates with increased total ACEs score had lower gestational age and birth weight. This is the rst study to our knowledge assessing ACEs of the neonate, but these ndings do align with existing literature on maternal ACEs which show increased total maternal ACEs associated with preterm birth and decreased birth weight (10,20). Studies have hypothesized that toxic maternal stress affects the fetus in utero resulting in adverse birth outcomes (12,20).…”

Section: Discussionsupporting

confidence: 82%

Incidence and Impact of Adverse Childhood Experiences in the Neonatal Intensive Care Unit

Sacotte,

Torr

2023

Preprint

View full text Add to dashboard Cite

Objective The objective of this study is to determine the incidence of documented ACEs for infants admitted to a neonatal intensive care unit (NICU) and assess for an association between neonatal ACEs and adverse outcomes. Study Design: A retrospective chart review was performed on all infants admitted to a Level III NICU for 6 months. Neonatal and maternal charts were reviewed for five ACEs: intimate partner violence, parental mental illness, incarceration, separation, and substance use. Result Data was collected for 203 infants. One or more ACEs were documented in 118 (58%) of infants and 3 or more ACEs in 12 (6%) of infants. Paternal mental illness was documented in only 1% (2) of infants. Conclusion The true incidence of neonatal ACEs remains unknown as most paternal data is not documented in the infant’s chart. There is an increased need to screen and document ACEs in infants admitted to the NICU to better understand the impact in this at risk population.

show abstract

Section: Discussionsupporting

confidence: 82%

Incidence and Impact of Adverse Childhood Experiences in the Neonatal Intensive Care Unit

Sacotte,

Torr

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…FGFR2 associated with obesity and weight at birth ( Haworth et al, 2014 ; Tian et al, 2018 ; Carboni et al, 2020 ) and with adult obesity ( Wu et al, 2014 ); DUSP22 related to diabetes and obesity ( Rizzo et al, 2020 ), and ZFP57 related to nutrition/neonatal diabetes ( Boonen et al, 2013 ). In consonance, the neglectful condition has been associated with having a preterm birth ( Sulaiman et al, 2021 ) with lower birth weight ( Strathearn et al, 2001 ) and with developing obesity over the life course ( Danese and Tan, 2014 ; Strathearn et al, 2020 ). ZFP57 ( Chen et al, 2019 ), FGFR2 ( Xi et al, 2014 ), and WNK4 ( Fackler et al, 2011 ), have been related to breast cancer, and WNK4 also with hypertension ( Mu et al, 2011 ; Ching et al, 2021 ) associated with suffering coronary heart disease ( Deschênes et al, 2021 ), conditions that are common among the long-term consequences of the abuse and neglect ( Strathearn et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

et al. 2022

View full text Add to dashboard Cite

Studies of DNA methylation have revealed the biological mechanisms by which life adversity confers risk for later physical and mental health problems. What remains unknown is the “biologically embedding” of maternal adverse experiences resulting in maladaptive parenting and whether these epigenetic effects are transmitted to the next generation. This study focuses on neglectful mothering indexed by a severe disregard for the basic and psychological needs of the child. Using the Illumina Human Methylation EPIC BeadChip in saliva samples, we identified genes with differentially methylated regions (DMRs) in those mothers with (n = 51), versus those without (n = 87), neglectful behavior that present similar DMRs patterns in their children being neglected versus non-neglected (n = 40 vs. 75). Mothers reported the emotional intensity of adverse life events. After covariate adjustment and multiple testing corrections, we identified 69 DMRs in the mother epigenome and 42 DMRs in the child epigenome that were simultaneously above the α = 0.01 threshold. The common set of nine DMRs contained genes related to childhood adversity, neonatal and infant diabetes, child neurobehavioral development and other health problems such as obesity, hypertension, cancer, posttraumatic stress, and the Alzheimer’s disease; four of the genes were associated with maternal life adversity. Identifying a shared epigenetic signature of neglect linked to maternal life adversity is an essential step in breaking the intergenerational transmission of one of the most common forms of childhood maltreatment.

show abstract

“…Adverse childhood experiences (ACEs) have been linked to multiple adult adverse health outcomes of psychological 75 and somatic 8,115 nature, including changes in peripartal mood and anxiety, 14,23,104,109 and preterm delivery. 14,104,109 A relationship of ACEs with chronic pain, 27,33 such as chronic widespread pain, 52 various functional somatic pain syndromes, 1,22 different forms of back pain, 22,56,59,61,63,64,69,81,96,98,107,111,125 and chronic pelvic pain, 46,57,58,83,87 is well established. Adverse childhood experiences encompass several types of experiences, of which maltreatment (ie, abuse and neglect) is particularly relevant for pain.…”

Section: Introductionmentioning

confidence: 99%

The association between adverse childhood experiences and peripartal pain experience

Zehetmeier

Fröhlich

Schilder

et al. 2023

PAIN

View full text Add to dashboard Cite

Adverse childhood experiences (ACEs) are associated with altered ongoing and evoked pain experiences, which have scarcely been studied for the peripartum period. We aimed to investigate how ACEs affect pain experience in pregnancy and labor. For this noninterventional trial with a short-term follow-up, pregnant women were divided into a trauma group (TG) with ACEs (n = 84) and a control group (CG) without ACEs (n = 107) according to the Childhood Trauma Questionnaire. Pain experience in pregnancy and labor was recorded by self-report and the German Pain Perception Scale. Pain sensitivity prepartum and postpartum was assessed by Quantitative Sensory Testing and a paradigm of conditioned pain modulation (CPM), using pressure pain thresholds (PPTs) and a cold pressor test. The TG showed higher affective and sensory scores for back pain and a more than doubled prevalence of preexisting back pain. Pelvic pain differences were nonsignificant. The TG also exhibited increased affective scores (1.71 ± 0.15 vs 1.33 ± 0.11), but not sensory scores for labor pain during spontaneous delivery. There were no group differences in prepartum pain sensitivity. While PPTs increased through delivery in the CG (clinical CPM), and this PPT change was positively correlated with the experimental CPM (r = 0.55), this was not the case in the TG. The association of ACEs with increased peripartal pain affect and heightened risk for preexisting back pain suggest that such women deserve special care. The dissociation of impaired clinical CPM in women with ACEs and normal prepartum experimental CPM implies at least partly different mechanisms of these 2 manifestations of endogenous pain controls.

show abstract

Total Adverse Childhood Experiences and Preterm Birth: A Systematic Review

Cited by 18 publications

References 34 publications

Incidence and Impact of Adverse Childhood Experiences in the Neonatal Intensive Care Unit

Incidence and Impact of Adverse Childhood Experiences in the Neonatal Intensive Care Unit

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

The association between adverse childhood experiences and peripartal pain experience

Contact Info

Product

Resources

About