Total Acid-Base Equilibrium of Plasma in Health and Disease

Peters, John P.; Wakeman, A. Maurice; Lee, C

doi:10.1172/jci100211

Cited by 37 publications

(8 citation statements)

References 7 publications

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“…58 Later, the term salt wasting nephritis was proposed to characterize a minority of patients with CKD who lose large amounts of NaCl in their urine. 59 The majority of patients with CKD have only a modest tendency to waste salt, as indicated by the fact that they cannot reduce urinary NaCl excretion promptly during dietary salt restriction.…”

Section: Salt Wasting In Ckdmentioning

confidence: 99%

Treatment of Disorders of Sodium Balance in Chronic Kidney Disease

Ellison

2017

Advances in Chronic Kidney Disease

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Extracellular fluid volume expansion is nearly universal in patients with chronic kidney disease. Such volume expansion often overlaps with the syndrome of heart failure with preserved ejection fraction, which can not only lead to symptoms, but can also lead to further organ damage. Unique treatment challenges are present in this patient population, including low glomerular filtration, which limits sodium chloride filtration, intrinsic tubule predisposition to sodium chloride retention, and proteinuria. Additionally, pharmacokinetic considerations alter the disposition of diuretics in patients with chronic kidney disease and nephrotic syndrome. Maintaining extracellular fluid volume near to normal is often necessary for hypertension treatment in this population, but it may also help prevent progressive cardiovascular and renal damage. Although powerful diuretics can often accomplish this goal, this often comes at a cost of competing side effects. An approach to reduce extracellular fluid volume while avoiding side effects, therefore, requires a nuanced yet aggressive therapeutic approach.

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Section: Salt Wasting In Ckdmentioning

confidence: 99%

Treatment of Disorders of Sodium Balance in Chronic Kidney Disease

Ellison

2017

Advances in Chronic Kidney Disease

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“…According to Fleure,2 the inhabitants of northwestern Europe south of the arctic circle, since the passing away of the ice ages, have lived under 1 conditions of humidity and mildness, with much cloud.…”

Section: The Skin and Racial Adaptations To Climatementioning

confidence: 99%

The Skin and Racial Adaptations to Climate

1928

JAMA

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“…In rare cases the sodium depletion becomes clinically obvious as reported by Thorn, Koepf and Clinton (1944) and they coined the term 'salt-losing nephritis'. It was Peters et al (1929), however, who first identified a group of uraemic patients with an excessive urinary chloride and for whom a daily addition of 7-10 g of sodium chloride to the diet was recommended. Since 1944, some 50 cases of saltlosing nephropathy have been reported (Joiner and Thorne, 1952;Enticknap, 1952;Levere and Wesson, 1956;Cove-Smith and Knapp, 1973;Popovtzer et al, 1973) and it is now obvious that many renal conditions can cause it.…”

Section: Introductionmentioning

confidence: 99%

Obstructive sodium-losing nephropathy--a case report and review

Nunn

Owens

Scholberg

et al. 1981

Postgraduate Medical Journal

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Summary The third case in the literature of sodium-losing renal disease due to obstruction is presented. The experimental evidence and limited clinical experience is reviewed which suggests that the sodium loss is due to an inappropriate response in the adaptive processes that are initiated by the loss of functioning nephrons. The immediate treatment is by replacement of sodium but in the long term the condition may be reversed by very cautious reduction in sodium intake. Definitive treatment may be indicated where obstruction is the cause and consequently this should be sought in all cases of salt-losing renal disease.

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Total Acid-Base Equilibrium of Plasma in Health and Disease

Cited by 37 publications

References 7 publications

Treatment of Disorders of Sodium Balance in Chronic Kidney Disease

Treatment of Disorders of Sodium Balance in Chronic Kidney Disease

The Skin and Racial Adaptations to Climate

Obstructive sodium-losing nephropathy--a case report and review

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