Toscana Virus Central Nervous System Infections in Southern Italy

Nicuolo, Giuseppe Di; Pagliano, Pasquale; Battisti, Sonia; Starace, Maria; Mininni, Vera; Attanasio, Vittorio; Faella, Francesco Saverio

doi:10.1128/jcm.43.12.6186-6188.2005

Cited by 37 publications

(36 citation statements)

References 14 publications

(14 reference statements)

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“…In other Italian regions, like Piedmont, Northern Italy (Pugliese, Beltramo, & Torre, 2007), Emilia Romagna, Central Italy (Portolani et al, 2002), and in Campania, Southern Italy (Di Nicuolo et al, 2005), seropositivity rates were much lower to negligible and exposed individuals tended to be asymptomatic.…”

Section: Epidemiology and Geographic Distributionmentioning

confidence: 94%

Personality Changes After Toscana Virus (TOSV) Encephalitis in a 49-Year-Old Man: A Case Report

Serata¹,

Rapinesi²,

Casale³

et al. 2010

International Journal of Neuroscience

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Toscana virus (TOSV) infection may often cause symptomatic meningitides and encephalitides. These usually subside in few days and their sequelae do not last for more than few weeks. We here report the case of a 49-year-old man who developed encephalitis after being bitten by phlebotomi in a region near southern Tuscany, where TOSV is endemic, and who developed postencephalitic seizures and subsequently, persistent personality alterations, characterized by sexually dissolute behavior and aggressiveness. One year after infection, the patient needs a combination of an SSRI antidepressant and a mood stabilizer/anticonvulsant to obtain less than optimal symptom improvement. This points to the need of establishing better preventive measures in Tuscany and nearby regions.

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Section: Epidemiology and Geographic Distributionmentioning

confidence: 94%

Personality Changes After Toscana Virus (TOSV) Encephalitis in a 49-Year-Old Man: A Case Report

Serata¹,

Rapinesi²,

Casale³

et al. 2010

International Journal of Neuroscience

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“…Most studies on the role of TOSV in central nervous system (CNS) disease have been conducted in continental Italy (Braito et al, 1998;Francisci et al, 2003;Di Nicuolo et al, 2005), and more recently in Spain and France (SanbonmatsuGamez et al, 2005;Charrel et al, 2007); little information is available in other Mediterranean areas, including islands.…”

mentioning

confidence: 98%

Detection of Toscana virus central nervous system infections in Sardinia Island, Italy

Venturi

Madeddu

Rezza

et al. 2007

Journal of Clinical Virology

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“…Transmitted primarily by mosquitoes, RVF virus is a significant human and veterinary pathogen capable of causing explosive outbreaks of disease, ranging from mild febrile illness to hemorrhagic fever, throughout Africa and, more recently, the Arabian peninsula (3). TOS and SFS viruses are principally vectored by Phlebotomine sand flies and can cause mild febrile illness or encephalitic syndromes in humans (9,23). While TOS virus is limited in geographic distribution to southern Europe, SFS virus is more widely spread and is found throughout Europe, the Mediterranean region, the Middle East, and northern Africa (6,10).…”

mentioning

confidence: 99%

A Shared Transcription Termination Signal on Negative and Ambisense RNA Genome Segments of Rift Valley Fever, Sandfly Fever Sicilian, and Toscana Viruses

Albariño

Bird

Nichol

2007

J Virol

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The Phlebovirus genus (family Bunyaviridae) is composed of a diverse group of arboviruses that cause disease syndromes ranging from mild febrile illness to hemorrhagic fever with high fatality. Although antigenically similar, these viruses differ by approximately 25% at the genome level, and their ecologies, including geographic ranges, preferred vector species, and hosts, vary considerably. In contrast to other ambisense viruses, where RNA hairpin structures which serve as transcription termination signals are frequently found separating the opposite-sense open reading frames, no evidence of predicted high-energy hairpin structures was found at the ambisense junctions of phlebovirus S RNA segments. However, a conserved sequence motif was identified on both negative and ambisense genome segments that functions as a transcription termination signal for the N, NSs, and GPC mRNAs in three diverse phleboviruses, namely, Rift Valley fever, sandfly Sicilian, and Toscana viruses. The exact termination of nascent virus mRNA molecules was determined by 3 rapid amplification of cDNA ends. Surprisingly, analysis of the termini of mRNAs from both S and M segments of these three viruses revealed that transcription termination occurred immediately upstream of a conserved sequence motif with the general features 3-C 1-3 GUCG/A-5. In contrast, no corresponding sequence motif was found in the L segments, and analysis indicated a "runoff" transcript approach to L mRNA termination. The absolute requirement of the identified transcription termination motif was demonstrated by using a highly efficient Rift Valley fever virus reverse genetics system to generate live recombinant viruses with S segments lacking the termination signal motif for the NP or NSs mRNA and showing that these recombinant viruses generated mRNAs that failed to terminate correctly.

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Toscana Virus Central Nervous System Infections in Southern Italy

Cited by 37 publications

References 14 publications

Personality Changes After Toscana Virus (TOSV) Encephalitis in a 49-Year-Old Man: A Case Report

Personality Changes After Toscana Virus (TOSV) Encephalitis in a 49-Year-Old Man: A Case Report

Detection of Toscana virus central nervous system infections in Sardinia Island, Italy

A Shared Transcription Termination Signal on Negative and Ambisense RNA Genome Segments of Rift Valley Fever, Sandfly Fever Sicilian, and Toscana Viruses

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