Vahbiz Jokhi, James Ashley, John Nunnari, Akiko Noma, Naoto Ito, Noriko Wakabayashi-Ito, Melissa J. Moore, Vivian Budnik
A previously unrecognized mechanism by which large ribonucleoprotein (megaRNP) granules exit the nucleus is by budding through the nuclear envelope (NE). This mechanism is akin to the nuclear egress of Herpes-type viruses and is essential for proper synapse development. However, the molecular machinery required to remodel the NE during this process is unknown. Here we identify Torsin, a AAA-ATPase that in humans is linked to dystonia, as a major mediator of primary megaRNP envelopment during NE-buddin…
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