2007
DOI: 10.1055/s-2007-992147
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Torsade de Pointes during Combined Treatment with Risperidone and Citalopram

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Cited by 22 publications
(15 citation statements)
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“…Of the male subjects, 18 had a QT interval of > 450 ms and 1 had a QT interval of > 480 ms. Of the female subjects, 47 had a QT interval of > 450 ms and 6 had a QT interval of > 480 ms. Our data confi rmed female gender as a risk for QT interval prolongation [ 4 ] . Despite one report which indicates a risk of life-threatening arrhythmia through use of multiple QT prolongation potentiating drugs [ 11 ] , no signifi cant diff erence in QTc interval between monotherapy and polymedication was found [analysis of variance, F(1, 501) = 1.11, p = 0.22] in our research.…”
Section: Discussioncontrasting
confidence: 99%
“…Of the male subjects, 18 had a QT interval of > 450 ms and 1 had a QT interval of > 480 ms. Of the female subjects, 47 had a QT interval of > 450 ms and 6 had a QT interval of > 480 ms. Our data confi rmed female gender as a risk for QT interval prolongation [ 4 ] . Despite one report which indicates a risk of life-threatening arrhythmia through use of multiple QT prolongation potentiating drugs [ 11 ] , no signifi cant diff erence in QTc interval between monotherapy and polymedication was found [analysis of variance, F(1, 501) = 1.11, p = 0.22] in our research.…”
Section: Discussioncontrasting
confidence: 99%
“…88 Like other antipsychotic agents, application of risperidone can also induce alterations in myocardial repolar ization. [91][92][93][94] A meta-analysis suggested a significantly elevated incidence of cardiac events compared with placebo. 95 A marked prolongation of cardiac repolar ization at supratherapeutic doses was observed in a dog model.…”
Section: Antipsychotic and Antidepressant Drugsmentioning
confidence: 99%
“…In other reports, cardiac effects have been found to occur when a selective serotonin reuptake inhibitor has been administered in combination with other drugs that are independently capable of prolonging QTc 68,69. Elsewhere, the association between selective serotonin reuptake inhibitor administration and the occurrence of QTc prolongation may be explained by the coexistence of other factors, including hypokalemia and hypomagnesemia 70,71.…”
Section: Differential Risk Between Antidepressant Classesmentioning
confidence: 96%