Abstract-In this paper, a review on applications of hydrothermal treatment (HTT) for upgrading waste materials was presented. This work was focused on pilot-scale HTT processes that applied to several kinds of waste for alternative solid biofuel production. The HTT utilizes subcritical water condition that has special properties as an organic solvent. With the temperature around 180-240 °C and the corresponding pressure that keeps the water in the liquid phase, many reactions are induced by the subcritical water such as hydrolysis and dehydration. The waste materials that had been subjected to the HTT processes by pilot-scale reactors such as paper sludge, antibiotic residue, and municipal solid waste were reviewed herein. Moreover, a novel application of HTT on hospital waste treatment has been carried out in a pilot-scale level. Results showed positive effects and consistency with the previous research works. Thus, the HTT showed possibility to be an option for pretreating waste materials prior to final conversion processes.Index Terms-Hydrothermal treatment, high moisture waste, pilot-scale hydrothermal, solid biofuel.