Torque Teno Virus (TTV) distribution in healthy Russian population

Vasilyev, Evgeny; Trofimov, Trofimov D.Yu.; Tonevitsky, Alexander G.; Ilinsky, Valery; Korostin, Dmitriy; Rebrikov, Denis V.

doi:10.1186/1743-422x-6-134

Cited by 77 publications

(73 citation statements)

References 24 publications

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“…The virus is common in general populations where it produces chronic infections. The percentage of infected subjects seems to be unrelated to gender [56][57][58][59]. The blood transfusion route cannot explain our results as none of the selected subjects had received blood transfusions or surgical interventions.…”

Section: Discussioncontrasting

confidence: 44%

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cimponeriu

Serafinceanu²,

Apostol

et al. 2013

Open Life Sciences

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Polymorphisms in IL6, ACE and ATR genes are associated with obesity. Torque Teno virus (TTV) seems to be able to interfere with production of some proinflammatory cytokines associated with obesity and related phenotypes. The aim of this study was to test the potential association between obesity, TTV infection and the IL6 G-174C (rs1800795), ACE I/D (rs4646994), AT1R A1166C (rs5186) polymorphisms. The polymorphisms and the presence of TTV were detected in blood samples from 150 obese and 150 normal-weight, healthy subjects using PCR based methods. IL6-174 CC genotype was more frequent in all obese patients (P=0.02) and in patients without TTV infections (P=0.03) than in controls. Obese women had more frequent TTV infections compared with normal-weight women (P=0.046). Obese subjects, regardless of gender (women P=0.03, men P=0.04), and healthy normal-weight men (P<0.01) carriers of AT1R C allele had higher triglycerides levels compared with non-carriers. The frequency of TTV in the control group (70.67%) was similar to data reported in other populations. The present study indicated that IL6-174 CC genotype and TTV infections in women could be associated with the common form of obesity.

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Section: Discussioncontrasting

confidence: 44%

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cimponeriu

Serafinceanu²,

Apostol

et al. 2013

Open Life Sciences

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“…Exposure to TTV is nearly universal. 31, 32 While TTV has not been definitively linked to any specific human disease, high titers of TTV in the serum have been associated with multiple sclerosis, systemic lupus erythematosis, hepatitis, rheumatic diseases, asthma, and fever of unknown origin (reviewed in 33 ). In two previous survey studies, TTV was isolated from the tears of 59% 34 and 66% 35 of subjects.…”

Section: Discussionmentioning

confidence: 99%

Identification of Torque Teno Virus in Culture-Negative Endophthalmitis by Representational Deep DNA Sequencing

et al. 2015

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Purpose To test the hypothesis that uncultured organisms may be present in cases of culture-negative endophthalmitis, by use of deep DNA sequencing of vitreous biopsies. Design Single center consecutive prospective observational study. Participants and Controls Aqueous or vitreous biopsies from 21 consecutive patients presenting with presumed infectious endophthalmitis, and seven vitreous samples from patients undergoing surgery for non-infectious retinal disorders. Methods Traditional bacterial and fungal culture, 16S quantitative polymerase chain reaction (qPCR) and a representational deep-sequencing method (Biome Representational in Silico Karyotyping [BRiSK]) were applied in parallel to samples to identify DNA sequences corresponding to potential pathogens. Main Outcome Measures Presence of potential pathogen DNA in ocular samples. Results None of 7 control eyes undergoing routine vitreous surgery yielded positive results for bacteria or virus by culture or 16S PCR. Fourteen of the 21 samples (66.7%) from eyes harboring suspected infectious endophthalmitis were culture-positive, the most common being Staphylococcal and Streptococcal species. There was good agreement among culture, 16S bacterial PCR, and BRiSK methodologies for culture-positive cases (Fleiss’ kappa of 0.621). 16S PCR did not yield a recognizable pathogen sequence in any culture-negative sample, while BRiSK suggested presence of Steptococcus in one culture-negative sample. Surprisingly, using BRiSK, 57.1% of culture-positive and 100% of culture-negative samples demonstrated presence of Torque Teno Virus (TTV) sequences, compared to none in the controls (Fisher exact, p = 0.0005). Presence of TTV viral DNA was confirmed in seven cases by qPCR. No other known viruses or potential pathogens were identified in these samples. Conclusion Culture, 16S qPCR, and BRiSK provide complementary information in presumed infectious endophthalmitis. The majority of culture-negative endophthalmitis samples did not contain significant levels of bacterial DNA. ‘culture-negativity’ does not appear to be due to failure of growth of fastidious bacteria. The small DNA virus TTV was unexpectedly found in all culture-negative samples and some culture-positive samples. The current study cannot distinguish whether TTV is a direct intraocular pathogen, an adjuvant for inflammation, a general marker of inflammation, or a commensal virus, but provides a testable hypothesis for a pathogenic mechanism in culture-negative endophthalmitis.

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“…This virus is distributed around the world and the prevalence of TTV infection is similarly high in all groups tested, including patients with liver (Asim et al 2010), acute respiratory (Maggi et al 2003) and renal diseases (Irshad et al 2010), as well as in human immunodeficiency virus (HIV)-positive subjects (Devalle & Niel 2004), drug users (Alzahrani et al 2009) and healthy individuals (Vasilyev et al 2009). The objective of the present study was to determine the prevalence of TTV DNA in blood donors and patients requiring haemodialysis in the southern state of Rio Grande do Sul (RS), Brazil.…”

mentioning

confidence: 99%

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Massaú

Martins

Nachtigal

et al. 2012

Mem. Inst. Oswaldo Cruz

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Torque Teno Virus (TTV) distribution in healthy Russian population

Cited by 77 publications

References 24 publications

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Identification of Torque Teno Virus in Culture-Negative Endophthalmitis by Representational Deep DNA Sequencing

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

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