Torque teno virus infection in hemodialysis patients in North India

Abstract

This study describes the prevalence and association of Torque teno virus (TTV) infection with blood-transmitted viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in patients with chronic renal failure (CRF) on maintenance hemodialysis (HD). TTV infection was diagnosed by detection of TTV-DNA in serum, using the polymerase chain reaction (PCR) technique. TTV-DNA was estimated in a total number of one hundred patients with CRF and in 100 voluntary blood donors as controls. The markers of HBV and HCV were also tested in sera samples of these patients. TTV-DNA was detected in 39 of 100 patients (39%) with CRF and in 27 of 100 (27%) healthy controls. The analysis of the results demonstrated HBsAg, IgM anti-HBc, anti-HCV, and HCV core antigen in 5.0, 3.0, 6.0, and 4.0% of patients, respectively. This study could not show any association of TTV with HBV and HCV infections for the transmission pattern or any impact on severity of diseases caused by these viruses in CRF patients. TTV also could not show any association with demographic characteristics of patients, duration of dialysis, number of blood transfusions and renal/liver function of the patients. As such, this study concludes that TTV appears as a benign pathogen, showing no sign of renal/liver damage or any change in the severity of diseases caused by blood-borne hepatitis viruses.

The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

“…This finding is in agreement with the results of previous studies (Chattopadhyay et al 2005, Irshad et al 2010. Consistent with the results of Irshad et al (2010), no biochemical evidence of a link between liver disease and TTV infection was observed in the TTV DNA-positive haemodialysis patients. Furthermore, elevated serum ALT levels were more closely linked to HCV than to TTV.…”

“…The prevalence (68.8%) detected among these patients was higher than the prevalence observed among patients requiring haemodialysis from other countries, which ranged from 16-58.5% (Martinez et al 2000, Irshad et al 2010). Such differences may be explained by the existence of different routes of virus transmission and lifestyle differences among different populations around the world.…”

“…This virus is distributed around the world and the prevalence of TTV infection is similarly high in all groups tested, including patients with liver (Asim et al 2010), acute respiratory (Maggi et al 2003) and renal diseases (Irshad et al 2010), as well as in human immunodeficiency virus (HIV)-positive subjects (Devalle & Niel 2004), drug users (Alzahrani et al 2009) and healthy individuals (Vasilyev et al 2009). The objective of the present study was to determine the prevalence of TTV DNA in blood donors and patients requiring haemodialysis in the southern state of Rio Grande do Sul (RS), Brazil.…”

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

“…[27] çalışmasında ise normal popülasyonla hemodiyaliz hastalarında TTV seroprevalansı arasında fark saptanmamış ve kanla bulaşan diğer viral hepatitlerle birlikteliği arasında bir ilişki bulunmamıştır. Usta ve ark.…”

Development of an Immunoassay for Detection of Torque Teno Virus (TTV) Antibodies Using the N22 Expression Product from TTV Genotype 2

“…The virus has been detected in nearly all tissues of the body [22]. Several studies point towards its association with liver and renal diseases [23][24][25]. It has also been detected in various types of carcinoma including leukemia and colorectal cancer.…”