Toripalimab plus chemotherapy and radiotherapy for treatment-naive, advanced esophageal squamous cell carcinoma: A single-arm phase II trial
Lei Wu,
Baisen Li,
Gang Wan
et al.
Abstract:Background
The effectiveness of chemo-immunotherapy for advanced esophageal squamous cell carcinoma (ESCC) remains limited. Therefore, we evaluated the safety and efficacy of radiotherapy plus chemo-immunotherapy as a first-line therapy for advanced ESCC.
Methods
In this single-arm clinical trial, individuals aged 18–75 years with previously untreated stage IV ESCC received chemotherapy comprising four cycles of 135–175 mg/m2 paclitaxel with carboplatin every three weeks. Toripalimab (240 mg) was intravenous… Show more
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