Torilin from<i>Torilis japonica,</i>as a New Inhibitor of Testosterone 5α-Reductase

doi:10.1055/s-2003-39717

Cited by 17 publications

(1 citation statement)

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“…In this study, avicequinone C showed its 5α-R1 inhibitory activity, with an IC 50 value of 38.8 ± 1.29 µM. Although this value indicates moderate potency, it is still better than or equivalent to the reported IC 50 values of many natural products isolated from plants, for example, the IC 50 values of 112 µM for soyasaponin1 from Pueraria thomsonii [20], 85 µM for artocarpin from Artocarpus incises [35], 40 µM for emodin from Polygonum multiflorum Thunb [36], 31.7 µM for triolin from Torillis japonica [37], 390 µM, 230 µM, 220 µM and 220 µM for 1,7-diphenylhept-4-en-3-one, dihydroyashabushiketol, 5-hydroxy-7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-3-heptanone and 5-hydroxy-7-(4''-hydroxyphenyl)-1-phenyl-3-heptanone from Alpinia officinarum [38] and 44 µM, 103 µM and 48 µM for (‒)-cubebin, (‒)-3,4-dimethoxy-3,4-desmethylenedioxycubebin and piperine from Piper nigrum , respectively [39].…”

Section: Resultsmentioning

confidence: 89%

Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

et al. 2014

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Avicennia marina (AM) exhibits various biological activities and has been traditionally used in Egypt to cure skin diseases. In this study, the methanolic heartwood extract of AM was evaluated for inhibitory activity against 5α-reductase (5α-R) [E.C.1.3.99.5], the enzyme responsible for the over-production of 5α-dihydrotestosterone (5α-DHT) causing androgenic alopecia (AGA). An AGA-relevant cell-based assay was developed using human hair dermal papilla cells (HHDPCs), the main regulator of hair growth and the only cells within the hair follicle that are the direct site of 5α-DHT action, combined with a non-radioactive thin layer chromatography (TLC) detection technique. The results revealed that AM is a potent 5α-R type 1 (5α-R1) inhibitor, reducing the 5α-DHT production by 52% at the final concentration of 10 µg/mL. Activity-guided fractionation has led to the identification of avicequinone C, a furanonaphthaquinone, as a 5α-R1 inhibitor with an IC 50 of 9.94 ± 0.33 µg/mL or 38.8 ± 1.29 µM. This paper is the first to report anti-androgenic activity through 5α-R1 inhibition of AM and avicequinone C.

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Section: Resultsmentioning

confidence: 89%

Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

et al. 2014

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A Review on Torilis japonica: Ethnomedicinal, Phytochemical, and Biological Features

Rahimpour

Doorandishan

Dehsheikh

et al. 2023

Chemistry & Biodiversity

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The present study was aimed at comprehensive overviewing a phytochemically and biologically important species namely Torilis japonica (Apiaceae family). Treatment of dysentery, fever, haemorrhoids, spasm, uterine tumors, lymphadenitis, rheumatism, impotence, infertility, women's diseases, and chronic diarrhea are reported as the main folk medicinal applications of the T. japonica fruits. So far, the plant is phytochemically characterized for its diverse terpene derivatives, predominantly sesquiterpenes. The plant's fruit is a rich source of torlin, a guaiane-type sesquiterpene, possessing various potent bioactivities. To date, anticancer, anti-inflammatory, antimicrobial, antioxidant, skin photoaging activities of the plant extracts and its constituents have been evaluated. Further investigation of the plant, specifically bioassay-guided isolation and identification of its major bioactive constituents can lead to discover potential phytopharmaceutical candidates.

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Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

Lü

2013

Parasitology Research Monographs

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Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis, a widespread infection, with clinical spectrum ranging from a completely asymptomatic infection to multiorgan involvement. Novel medicines effective against both active and latent forms of the parasite are greatly needed. To review current evidence for antitoxoplasmosis by Traditional Chinese Medicine (TCM), our literature focused on five kinds of Chinese herbs, including Torilis japonica, Zingiber officinale, Sophora flavescens, Astragalus membranaceus, and Scutellaria baicalensis GEORGI in our present study, which are used in TCM for the treatment of allergic inflammatory diseases, infectious diseases such as bacterial infection, virus infection, helminthiasis, etc., and the mentioned TCM whose antiapicomplexan activity have been previously reported. In conclusion, TCM possess promising activity in vivo and in vitro against T. gondii, and the components of TCM deserve further study.

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Torilin fromTorilis japonica,as a New Inhibitor of Testosterone 5α-Reductase

Cited by 17 publications

References 15 publications

Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

Avicequinone C Isolated from Avicennia marina Exhibits 5α-Reductase-Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

A Review on Torilis japonica: Ethnomedicinal, Phytochemical, and Biological Features

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

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