TORC1 reactivation by pheromone signaling revealed by phosphoproteomics of fission yeast sexual reproduction
Melvin Bérard,
Laura Merlini,
Sophie G Martin
Abstract:Starvation, which is associated with inactivation of the growth-promoting TOR complex 1 (TORC1), is a strong environmental signal for cell differentiation. In the fission yeastSchizosaccharomyces pombe, nitrogen starvation has distinct physiological consequences depending on the presence of mating partners. In their absence, cells enter quiescence, and TORC1 inactivation prolongs their life. In presence of compatible mates, TORC1 inactivation is essential for sexual differentiation. Gametes engage in paracrine… Show more
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