Torasemide

Stirling, Angus; Fisher, Miles

doi:10.1002/pdi.2174

Cited by 1 publication

(1 citation statement)

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“…1), chemically known as N-(isopropylcarbamoyl)-4-(m-tolylamino) pyridine-3-sulfonamide and approved in Belgium in 1993 and in China in 2003, is a highly potent, selective, long-acting, and orally bioavailable loop diuretic for the treatment of hypertension and edema caused by congestive heart failure, kidney or liver disease. [7][8][9][10] It occupies most of the market share of high-potency diuretics due to its strong diuretic effect, high bioavailability, longlasting effect, and good safety. 7 The synthesis and identification of process-related substances play a vital role in the process of quality control.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Related Substances of Torasemide

Chen

Ming

Fan³

et al. 2022

Pharmaceutical Fronts

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Torasemide, a pyridine-3-sulfonylurea derivative, is a high-efficiency loop diuretic. During the process development of torasemide, five process-related substances, which have been specified in the pharmacopeia, would be produced. In this study, all these related substances, including compounds A–E, were synthesized via simple procedures and subsequently characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectrometry. Particularly, a simple synthetic method for compound A has not been found in previous literature. It is worth noting that other related substances could be prepared from compound B in one or two steps. The availability of these related substances could allow for quality control in the process of torasemide.

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Section: Introductionmentioning

confidence: 99%