This paper introduces a new method for the use of tensor-resistive sensors in large spherical storage tank equipment (over 12,000-mm diameters). We did an experiment with 19 petroleum or ammonia product sphere-shaped storage tanks with volumes of 1000 and 1800 cubic meters, respectively. The existing literature only contains experiments based on sensors for tanks with diameters no larger than 600 mm. Based on a number of resistive strain sensor measurements on large spherical pressurized vessels regarding structural integrity assessment, the present paper is focused on the comparison between "real-life" obtained sensor data versus finite element method (FEM) simulation results. The present paper is structured in three parts and examines innovative directions: the use of the classic tensor-resistive sensors in a new approach concerning large structural equipment; an original 3D modeling method with the help of the FEM; and conclusions with possible implications on the regulations, design, or maintenance as a result of the attempt of mutual validation of the new methods previously mentioned.Sensors 2020, 20, 525 2 of 21 requires the measurement of the internal pressure at the top of the sphere, due to the large diameter of the structure, the water column additionally strains the mantle in the bottom area with an extra 0.12 to 0.16 MPa; for some cases, this represents an overstrain of about 15-20%. The problem becomes even more complex when one needs to estimate the remaining service life of the installation according to existing regulations. As noted above, such tanks are critical equipment and it is important to test them for proper functioning, especially in the light of newer findings. For example, as reported in the paper, the stairs (which are not nationally or internationally regulated as constructive parts of large pressure vessels) may interfere with the proper functioning of the tanks.Most of the studies carried out in this field have focused on the pipe-type structures used with measurements performed by means of bidirectional tensor-resistive sensors [2,3], or studies carried out under laboratory conditions [4][5][6][7]. For example, Agbo et al. presented a study [1] that describes investigations performed using tensor-resistive sensors regarding the behavior of some thin-walled metal structures with an operating usage history and subjected to an internal pressure. In comparison with these laboratory studies, and from the point of view of both FEM simulations and the experimental approach, this paper addresses large spherical structures that require in situ treatment and the use of three-direction sensors.Regarding the way in which the thickness of the wall was treated in the FEM from the meshing point of view, Zhu et al. [5] approached the problem of resistance and stability by applying FEM on some spherical structures; however, they focused only on the manhole area, while the experiment was performed on some laboratory models (experimental verification using acrylonitrile butadiene styrene (ABS) scale ...