Abstract:Although RNAs play a critical role in all cellular processes, the elucidation of their 3D structures is a daunting task. Naked RNAs are difficult to crystallize, and NMR spectroscopy is generally limited to small RNA fragments. As there is little apparent correlation between RNA primary sequences and three--dimensional folding, the usefulness of a pure computational structure prediction approach is also limited. Currently, general methods for high throughput topological structure determination of RNAs, guided … Show more
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