Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
Alexandra Urbancokova,
Terezie Hornofova,
Josef Novak
et al.
Abstract:PML, a multifunctional protein, plays a crucial role in forming PML nuclear bodies, which are involved in various cellular processes, including stress responses. Under specific conditions, PML associates with nucleoli, forming PML nucleolar associations (PNAs). However, the stimuli leading to PNAs formation are unknown. Here we investigated these stimuli by exposure of cells to various genotoxic stresses. We reveal that the most potent inducers of PNAs share the ability to inhibit topoisomerases and RNA polyme… Show more
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