Topological Properties of Curcumin and Hyaluronic Acid Conjugated Molecular Structure: An Anti-Cancer Drug

Rauf, Abdul; Akram, Bushra; Ishtiaq, Muhammad; Siddiqui, Muhammad Kamran

doi:10.1080/10406638.2021.2014530

Cited by 2 publications

(1 citation statement)

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“…To overcome this conjugates of curcumin with Hyaluronic Acid(HA) has received appreciable attention in recent times not only for increasing bioavailability but also to target tumor cells and tumor metastases for the treatment of numerous cancer. Therefore, conjugates of curcumin with HA is regarded as promising pharmaceutical strategy to improve water solubility, prolong curcumin release at the target site, improve tissue distribution and potentiate therapeutic outcomes [30,37], computed many degree-based topological indices and polynomials.…”

Section: Introductionmentioning

confidence: 99%

Calculating PI Related Indices and Its Polynomial of Hyaluronic Acid and Conjugates

P.KANDAN¹,

SUBRAMANIAN²,

RAJESH³

2022

JIMS

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A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure. Drug properties can be obtained by studying the molecular structure of corresponding drugs. The calculation of the topological index of a chemical graph enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs. In this paper, we focus on Hyaluronic Acid-Curcumin/Paclitaxel conjugate which are widely used in the manufacture of anticancer drugs. Therefore in this paper we have computed the Padmakar-Ivan related indices and its polynomial of the Hyaluronic Acid-curcumin/paclitaxel conjugate by using edge partitioning technique.

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Section: Introductionmentioning

confidence: 99%