Given a cluster-tilted algebra B, we study its first Hochschild cohomology group HH 1 (B) with coefficients in the B-B-bimodule B. If C is a tilted algebra such that B is the relation-extension of C, then we show that if B is tame, then HH 1 (B) is isomorphic, as a k-vector space, to the direct sum of HH 1 (C) with k n B,C , where n B,C is an invariant linking the bound quivers of B and C. In the representation-finite case, HH 1 (B) can be read off simply by looking at the quiver of B.