Floquet engineering of photonic waveguide lattice could generate π-mode, which is localized at the end or corner of the one or two dimensional finite arrays, respectively. In this paper, we theoretically study the Floquet engineering of two dimensional photonic waveguide lattice in three types of lattices: honeycomb lattice with Kekule distortion, breathing square lattice and breathing Kagome lattice. The Kekule distortion factor or the breathing factor in the corresponding lattice is periodically changed along the axial direction of the photonic waveguide with frequency ω. Within certain ranges of ω, the Floquet π mode in a gap of quasi-energy spectrum are found, which are localized at the corner of the finite two-dimensional arrays. Due to particle-hole symmetric in the model of honeycomb and square lattice, the quasi-energy level of the Floquet π mode is ±ω/2. On the other hand, for Kagome lattice, the quasi-energy level of the Floquet π mode is near to ±2ω/3 or ∓4ω/3.