volume 83, issue 10, P1900-1913 2015
DOI: 10.1002/prot.24874
View full text
Sign up to set email alerts

Abstract: It has been suggested that proteins have substructures, called foldons, which can cooperatively fold into the native structure. However, several prior investigations define foldons in various ways, citing different foldon characteristics, thereby making the concept of a foldon ambiguous. In this study, we perform a Gō model simulation and analyze the characteristics of substructures that cooperatively fold into the native-like structure. Although some results do not agree well with the experimental evidence du…

Expand abstract