Topoisomerase ll-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells

Gulliya, Kirpal S.; Franck, Burchard; Schneider, Udo; Sharma, Radhakant; Arnold, Lauren; Matthews, James L.

doi:10.1097/00001813-199410000-00007

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The merocyanine 540 (MC 540), which belongs to the merocyanine type compounds, is an important liphophilic dye that has been studied extensively because of its application in photomedicine 13. Its photoproducts, merocil and merodantoin, show significant antitumor activity 14. However, there are limited theoretical data related to MC 540.…”

Section: Introductionmentioning

confidence: 99%

Ab initio study of electronic spectra of merocyanine 540 and its photoproducts

Mach¹,

Urban²,

Leszczyński³

2002

Int J of Quantum Chemistry

View full text Add to dashboard Cite

Molecular structures of three derivatives of merocyanine 540 (MC 540) were studied using the density functional method in conjunction with the 6-31G*, 6-31G**, and 6-311G** basis sets. The excited states were calculated using the configuration interaction method involving singly excited configurations (CIS). The predicted transition energies and oscillator strength agree well with the experimental UV adsorption spectra of the studied systems. The existence of two stable conformers of merocyanine explain the experimentally observed dependence of the UV spectra upon the change of concentration of added salts.

show abstract

Section: Introductionmentioning

confidence: 99%

Ab initio study of electronic spectra of merocyanine 540 and its photoproducts

Mach¹,

Urban²,

Leszczyński³

2002

Int J of Quantum Chemistry

View full text Add to dashboard Cite

show abstract

“…However, apoptosis is often characterised by endonucleolytic cleavage of DNA, which can be viewed by electrophoresis as a series of bands, or 'DNA ladder' (Wyllie, 1980;Arends et al, 1990). This particular approach has been employed with a number of topo inhibitors to determine the presence of apoptosis (Kaufmann, 1989;Walker et al, 1991;Gulliya et al, 1994;Huschtscha et al, 1995). DNA laddering, which can be reversed by zinc (Cohen and Duke, 1984), may not be an ideal marker for apoptosis as there have been a number of reports describing the morphological characteristics of apoptotic cells without internucleosomal cleavage Sun et al, 1994).…”

mentioning

confidence: 99%

Induction of apoptosis in human cancer cell lines by the novel anthracenyl-amino acid topoisomerase I inhibitor NU/ICRF 505

Meikle

Cummings²,

Macpherson³

et al. 1996

Br J Cancer

View full text Add to dashboard Cite

Summary Anthracenyl-amino acid conjugates represent a novel chemical class of topoisomerase (topo) inhibitor. NU/ICRF 505 is a lead compound that stabilises topo I cleavable complexes and is actively cytotoxic at low MM concentrations. In this study, endonucleolytic DNA cleavage was used as a marker of apoptosis to investigate mechanisms of cell death produced by this compound. NU/ICRF 505 (5 yM) induced a substantial increase in the level of DNA fragmentation in HL60 cells (up to 30% of total extracted DNA) but only after a 48 and 72 h drug exposure (compared with 6 h after treatment with camptothecin), as determined qualitatively by conventional gel electrophoresis and quantitatively by spectrofluorimetry. This effect was substantially reversed by co-treatment with zinc (1 mM). Subsequent studies with the human lung (NX002), ovarian (A2780) and colon (HT29) cancer cell lines yielded evidence of formation of higher molecular weight DNA fragments in NX002 and A2780 cells in response to NU/ICRF 505 (5 uM). Co-treatment with zinc (1 mM) caused a small decrease in DNA fragmentation. These data suggest that the induction of apoptosis may play an important role in the mechanism of cytotoxicity of NU/ICRF 505 in HL60 cells and that other pathways of cell death may also be operative in NX002 and A2780 in conjunction with apoptosis.

show abstract

Neuartige Porphyrinoide für Chemie und Medizin durch biomimetische Synthesen

Franck

Nonn

1995

Angewandte Chemie

Self Cite

View full text Add to dashboard Cite

Telefax: Int. + 2151188-7703 rechtfertigt, sie als Porphyrinoide zu bezeichnen, da sie alle aus einer gemeinsamen Biosynthesevorstufe, dem Uroporphyrinogen I11 3, hervorgehen (Schema l)L5-']. CO, H CO, H 1 2 Porphyrin Porphyrinogen COaH 3 Uroporphyrinogen 111 Schema 1. Strnktur der Porphyrinoide 1-3. Fur die Bedurfnisse der Organismen entwickelte die Natur eine Bioproduktion von Porphyrinoiden, deren Dimensionen abgeschatzt werden konnen. Beginnen wir mit dem Porphyrinoid Vitamin B,, , dessen Mange1 perniciose Anamie verursacht. Der Mensch benotigt nur die auI3erordentlich geringe Menge von taglich 0.001 mg Vitamin BIZ; das ergibt fur die gesamte Erdbevolkerung einen Jahresbedarf von etwa 2000 kg. Der zur

show abstract

Topoisomerase ll-dependent novel antitumor compounds merocil and merodantoin induce apoptosis in Daudi cells

Cited by 7 publications

References 0 publications

Ab initio study of electronic spectra of merocyanine 540 and its photoproducts

Ab initio study of electronic spectra of merocyanine 540 and its photoproducts

Induction of apoptosis in human cancer cell lines by the novel anthracenyl-amino acid topoisomerase I inhibitor NU/ICRF 505

Neuartige Porphyrinoide für Chemie und Medizin durch biomimetische Synthesen

Contact Info

Product

Resources

About