Abstract:Topoisomerase IIα (Topo IIα), a well-conserved double-stranded DNA (dsDNA)-specific decatenase, processes dsDNA catenanes resulting from DNA replication during mitosis. Topo IIα defects lead to an accumulation of ultrafine anaphase bridges (UFBs), a type of chromosome non-disjunction. Topo II has been reported to resolve DNA anaphase threads, possibly accounting for the increase in UFB frequency upon Topo IIinhibition. We hypothesized that the excess UFBs might also result, at least in part, from an impairm… Show more
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