Topography of the Human Corpus Callosum

Lacoste, M.-C. De; Kirkpatrick, Joel B.; Ross, Elliott D.

doi:10.1097/00005072-198511000-00004

Cited by 515 publications

(290 citation statements)

References 19 publications

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“…The software counted any inferior portion of C1 that extended underneath into the C2 section as part of C1. Our five subregions are very similar to those used by a study that examined of the topography of the corpus callosum [8].…”

Section: Image Processing Total Intracranial Volume and Corpus Callmentioning

confidence: 57%

“…The splenium consists of fiber tracts connecting the temporal-parietal-occipital cortex, the superior parietal region, and the occipital lobe [8]. Studies utilizing [ 18 F] fluorodeoxyglucose (FDG) positron emission tomography (PET) have shown that patients with AD have significantly reduced temporoparietal metabolism compared to healthy controls [1,15].…”

Section: Discussionmentioning

confidence: 99%

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Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Wang

Saykin

Flashman

et al. 2006

Neurobiology of Aging

102

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The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, and CC groups all showed a significant reduction of the posterior region (isthmus and splenium) relative to healthy controls. The AD group also had a significantly smaller overall callosum than the controls. The demonstration of callosal atrophy in older adults with cognitive complaints suggests that callosal changes occur very early in the dementing process, and that these earliest changes may be too subtle for detection by neuropsychological assessments, including memory tests.

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Section: Image Processing Total Intracranial Volume and Corpus Callmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Wang

Saykin

Flashman

et al. 2006

Neurobiology of Aging

102

View full text Add to dashboard Cite

show abstract

“…Monkey and human studies indicate that prefrontal, premotor and motor fibers cross through the anterior part of the corpus callosum, whereas temporal, parietal, and occipital fibers cross through the caudal part (de Lacoste et al, 1985;Pandya and Rosene, 1985;Pandya and Seltzer, 1986).…”

Section: Discussionmentioning

confidence: 99%

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Ballmaier

Kumar

Elderkin‐Thompson

et al. 2007

Neuropsychopharmacol

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There is some evidence of corpus callosum abnormalities in elderly depression, but it is not known whether these deficits are regionspecific or differ based on age at onset of depression. Twenty-four patients with early-onset depression (mean age ¼ 68.00, SD75.83), 22 patients with late-onset depression (mean age ¼ 74.50, SD78.09) and 34 elderly control subjects (mean age ¼ 72.38; SD76.93) were studied. Using 3D MRI data, novel mesh-based geometrical modeling methods were applied to compare the midsagittal thickness of the corpus callosum at high spatial resolution between groups. Neuropsychological correlates of midsagittal callosal area differences were additionally investigated in a subsample of subjects. Depressed patients exhibited significant callosal thinning in the genu and splenium compared to controls. Significant callosal thinning was restricted to the genu in early-onset patients, but patients with late-onset depression exhibited significant callosal thinning in both the genu and splenium relative to controls. The splenium of the corpus callosum was also significantly thinner in subjects with late-vs early-onset depression. Genu and splenium midsagittal areas significantly correlated with memory and attention functioning among late-onset depressed patients, but not early-onset depressed patients or controls. Circumscribed structural alterations in callosal morphology may distinguish late-from early-onset depression in the elderly. These findings suggest distinct abnormalities of cortical connectivity in late-and early-onset elderly depression with possible influence on the course of illness. Patients with a late onset of depression may be at higher risk of illness progression and eventually dementia conversion than earlyonset depression, with potentially important implications for research and therapy.

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“…Thus, there is a reduced ability for the left medial frontal region to be connected to the right temporal parietal region; this having been done through an indirect link via the right medial frontal region. Additionally, the genu of the corpus callosum may contain fibers by which the frontal and parietal regions cross (de Lacoste, Kirkpatrick, & Ross, 1985). This pattern of results suggests that the key regions involved in accomplishing the inferential processing tasks were less coordinated in autism and that this underconnectivity was more pronounced in connections between frontal and parietal regions.…”

Section: Inefficiency In the Theory Of Mind Network In Autismmentioning

confidence: 97%

Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism

et al. 2008

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The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum.

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Topography of the Human Corpus Callosum

Cited by 515 publications

References 19 publications

Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints

Mapping Callosal Morphology in Early- and Late-Onset Elderly Depression: An Index of Distinct Changes in Cortical Connectivity

Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism

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