Topography-guided identification of leakage point in central serous chorioretinopathy: a base for fluorescein angiography-free focal laser photocoagulation

Maltsev, Dmitrii S.; Kulikov, Alexei N.; Chhablani, Jay

doi:10.1136/bjophthalmol-2017-311338

Cited by 33 publications

(39 citation statements)

References 21 publications

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“…The Amsler grid test may be useful in demonstrating metamorphopsy. Hyperopia often develops in the affected eye (19)(20)(21)(22)(23). All cases we included in our study had typical CSC ndings in both FFA and OCT imaging (Fig.…”

Section: Discussionmentioning

confidence: 89%

Central Serous Chorioretinopathy And Selective Serotonin Reuptake Inhibitors

Altun

Atmaca

Icagasioglu³

et al. 2020

Preprint

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Aim: To investigate the relationship between central serous chorioretinopathy (CSC) and selective serotonin reuptake inhibitor (SSRI) antidepressant drugs.Methods: The files of patients diagnosed with CSC who applied to our clinics were analyzed retrospectively. Group 1 was formed from patients who had never used any antidepressant drug. Group 2 and Group 3 were composed of patients who did not stop and stopped using SSRI after the third month, respectively. Ophthalmological examinations, optical coherence tomography and fundus fluorescein angiography images of the patients were analyzed and the groups were compared with each other. Results: Group 1, Group 2 and Group 3 had 122, 8, 12 eyes, respectively. The time for complete resolution of subretinal fluid (SRF) in Group 3 was statistically significantly shorter than Group 1 and Group 2 (p ˂ 0.01). In Group 2, the time for complete resolution of SRF was significantly longer than Group 1 (p ˂ 0.05). Conclusion: SSRI group antidepressant drugs might be an important factor in CSC etiology and prognosis. Discontinuation of these drugs may accelerate subretinal fluid resolution.

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Section: Discussionmentioning

confidence: 89%

Central Serous Chorioretinopathy And Selective Serotonin Reuptake Inhibitors

Altun

Atmaca

Icagasioglu³

et al. 2020

Preprint

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“…Топографический анализ показал, что распределение отслоек нейроэпителия, зон альтерации ПЭС и точек просачивания не может быть случайным и не имеет исключительной топической ассоциации с центром Несмотря на то, что ранее также было показано, что отслойка ПЭС, относится к важным признакам точки просачивания, их топическое взаимное распределение не было продемонстрировано [6]. Более того, по результатам настоящей работы становиться ясно, что существует не просто связь между появлением точки просачивания с отслойкой ПЭС, но и соотношение между формированием просачивания и альтерацией пигментного эпителия в целом.…”

Section: обсуждение полученных данныхunclassified

Morphometric and topograpical analysis of retinal abnormalities in central serous chorioretinopathy

Maltsev¹,

Малахова²,

Kulikov³

et al. 2020

Tihookeanskij medicinskij žurnal

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Objective: Quantitative morphometric and topographic analysis of specific changes of the retina in patients with the acute central serous chorioretinopathy (CSC) based on annotated tomograms.Methods: 39 patients with the acute CSC (44 eyes – 45 scans) were examined. A complex ophthalmological examination was carried out including 3D optical coherence tomography of maculae. The data was uploaded into CVAT. Three classes of pathological changes were differentiated: 1) retinal neuroepi‑ thelium detachment; 2) retinal pigment epithelium alteration; 3) percolation zones. The analysis of topographical localization of changes and their morphological relations were assessed with a programming language Python.Results: A moderate trend towards vertical asymmetry of the neuroepithelial detachment zone with an excess of cumulative distribution in the lower part of the macula was revealed. Retinal pigment epithelium alteration sites and percolation zones demonstrated a relative peak of representation in the upper nasal part of the macula. In 69.9% and 80% of cases, respectively, abnormalities of retinal pigment epithelium and percolation zones were localized within the limits of neuroepithelial detachment. Direct correlation between the area of neuroepithelial detachment and the area of percolation zones; the area of percolation zones and the area of retinal pigment epithelium alteration; the area of neuroepithelial detachment and the area of retinal pigment epithelium alteration.Conclusions: Percolation zones and abnormalities of retinal pigment epithelium demonstrate similar trends in topo‑ graphical localization and quantitative characteristics and are related to the area of neuroepithelial detachment in CSC. Thus, the number of retinal pigment epithelium abnormalities can serve as an indicator of disease severity.

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“…Создание обучающего множества В соответствии с задачами обучения нейронной сети были выделены три категории патологических изменений: наличие субретинальной жидкости (1), аномалии ПЭС (2) и точек просачивания (3). Если категория присутствовала на трёхмерном скане, то отмечали координаты, ограничивающие её область.…”

Section: разметка данныхunclassified

“…Известным ограничением применения ОКТ для диагностики ЦСХ является невозможность идентифицировать точку просачивания, что необходимо не только для верификации диагноза, но и для лечения, в случае если оно показано. Тем не менее в нескольких работах было установлено, что идентификация точки просачивания с помощью ОКТ возможна по крайней мере у части пациентов с ЦСХ, однако такой подход достаточно сложен даже для опытного специалиста [3][4][5].…”

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Artificial intelligence and machine learning for optical coherence tomography-based diagnosis in central serous chorioretinopathy

Kulikov

Николаевич²,

Malahova

et al. 2019

Ophthalmology Reports

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The aim of the present study was to examine the potential of machine learning for identification of isolated neurosensory retina detachment and retinal pigment epithelium (RPE) alterations as diagnostic criteria of central serous chorioretinopathy (CSC). Material and methods. Patients with acute CSC in whom a standard ophthalmic examination and optical coherence tomography (OCT) using RTVue-XR Avanti (Angio Retina HD scan protocol, 6 6 mm) was performed were included in the study. 10-m en face slab above the RPE layer was used to create ground truth masks. Learning aims were defined as identification of 3 classes of structural abnormalities on OCT cross-sectional scans: class 1 subretinal fluid, class 2 RPE abnormalities, and class 3 leakage points. Data for each of the 3 classes included: 4800/1400 training/test images for class 1, 2000/802 training/test images for class 2, and 1504/408 training/test images for class 3. Unet-similar architecture was used for segmentation of abnormalities on OCT cross-sectional scans. Results. Analysis of test sets revealed sensitivity, specificity, precision, and F1-score for detection of subretinal fluid of 0.61, 0.99, 0.99, and 0.76, respectively. For detection of RPE abnormalities sensitivity, specificity, precision, and F1-score were 0.14, 0.95, 0.94 and 0.24, respectively. For detection of leakage point sensitivity, specificity, precision, and F1-score were 0.06, 1.0, 1.0, and 0.12, respectively. Conclusions. Thus, machine learning demonstrated high potential in the OCT-based identification of structural abnormalities associated with acute CSC (neurosensory retina detachment and RPE alterations). Topical identification of the leakage point appears to be possible using large learning sets.

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Topography-guided identification of leakage point in central serous chorioretinopathy: a base for fluorescein angiography-free focal laser photocoagulation

Cited by 33 publications

References 21 publications

Central Serous Chorioretinopathy And Selective Serotonin Reuptake Inhibitors

Central Serous Chorioretinopathy And Selective Serotonin Reuptake Inhibitors

Morphometric and topograpical analysis of retinal abnormalities in central serous chorioretinopathy

Artificial intelligence and machine learning for optical coherence tomography-based diagnosis in central serous chorioretinopathy

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